Bex2 Antibody (C-12): sc-398486
- Bex2 Antibody (C-12) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-22 at the N-terminus of Bex2 of human origin
- Anti-Bex2 Antibody (C-12) is recommended for detection of Bex2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Bex2 Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Bex2 Antibody (C-12) for WB applications. These reagents are now offered in bundles with Bex2 Antibody (C-12) (see ordering information below).
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Bex2 Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Bex2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bex2 (C-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The brain-expressed X-linked (Bex) family of proteins, including Bex2, plays a crucial role in the central nervous system, with significant expression levels found in the cerebellum, temporal lobe, and pituitary tissues. Bex2 is particularly important due to its involvement in neuronal differentiation and interaction with LMO2, a LIM domain-containing transcription factor that regulates the transcriptional activity of DNA-binding complexes. This interaction is vital for proper gene expression during neurodevelopment. Additionally, Bex2 is highly expressed in the embryonic brain and shuttles between the cytoplasm and nucleus, which is essential for regulatory functions. Notably, Bex2 has been implicated in tumor formation, as upregulation can lead to increased sensitivity to chemotherapy-induced apoptosis, while also exhibiting powerful tumor suppressor effects.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bex2 Antibody (C-12) References:
- Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. | Brown, AL. and Kay, GF. 1999. Hum Mol Genet. 8: 611-9. PMID: 10072429
- Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos. | Williams, JW., et al. 2002. Mol Reprod Dev. 61: 281-7. PMID: 11835573
- Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. | Yang, QS., et al. 2002. Biochem Genet. 40: 1-12. PMID: 11989783
- Immunolocalization of Bex protein in the mouse brain and olfactory system. | Koo, JH., et al. 2005. J Comp Neurol. 487: 1-14. PMID: 15861462
- Characterization of the Bex gene family in humans, mice, and rats. | Alvarez, E., et al. 2005. Gene. 357: 18-28. PMID: 15958283
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. | Han, C., et al. 2005. Nucleic Acids Res. 33: 6555-65. PMID: 16314316
- Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. | Vilar, M., et al. 2006. EMBO J. 25: 1219-30. PMID: 16498402
- Analysis of optic nerve stroke by retinal Bex expression. | Bernstein, SL., et al. 2006. Mol Vis. 12: 147-55. PMID: 16541015
- Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. | Foltz, G., et al. 2006. Cancer Res. 66: 6665-74. PMID: 16818640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bex2 Antibody (C-12) | sc-398486 | 200 µg/ml | $316.00 | |||
Bex2 Antibody (C-12): m-IgG Fc BP-HRP Bundle | sc-530817 | 200 µg Ab; 10 µg BP | $354.00 | |||
Bex2 Antibody (C-12): m-IgGκ BP-HRP Bundle | sc-524362 | 200 µg Ab, 40 µg BP | $354.00 | |||
Bex2 Antibody (C-12): m-IgG1 BP-HRP Bundle | sc-544264 | 200 µg Ab; 20 µg BP | $354.00 | |||
Bex2 Antibody (C-12) AC | sc-398486 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Bex2 Antibody (C-12) HRP | sc-398486 HRP | 200 µg/ml | $316.00 | |||
Bex2 Antibody (C-12) FITC | sc-398486 FITC | 200 µg/ml | $330.00 | |||
Bex2 Antibody (C-12) PE | sc-398486 PE | 200 µg/ml | $343.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 488 | sc-398486 AF488 | 200 µg/ml | $357.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 546 | sc-398486 AF546 | 200 µg/ml | $357.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 594 | sc-398486 AF594 | 200 µg/ml | $357.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 647 | sc-398486 AF647 | 200 µg/ml | $357.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 680 | sc-398486 AF680 | 200 µg/ml | $357.00 | |||
Bex2 Antibody (C-12) Alexa Fluor® 790 | sc-398486 AF790 | 200 µg/ml | $357.00 | |||
Bex2 (C-12) Neutralizing Peptide | sc-398486 P | 100 µg/0.5 ml | $68.00 |