Bex1/2 Antibody (D-6): sc-376342
- Bex1/2 Antibody (D-6) is a mouse monoclonal IgG1 κ Bex1/2 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 39-110 mapping within an internal region of Bex1 of human origin
- Bex1/2 Antibody (D-6) is recommended for detection of Bex1 and Bex2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Bex1/2 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bex1/2 Antibody (D-6). This work is in progress.
Bex1/2 Antibody (D-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Bex1/2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Bex1/2 (D-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The brain-expressed X-linked (Bex) family of proteins is predominantly expressed in the central nervous system, with highest levels found in the cerebellum, temporal lobe, and pituitary tissues. Bex1 is crucial for neuronal differentiation in response to nerve growth factor (NGF) and plays a significant role in cell cycle progression. Notably, Bex1 functions as a highly ubiquitinated protein that serves as a critical link between the cell cycle and neurotrophic factor signaling pathways. Additionally, Bex2 interacts with LMO2, which regulates transcriptional activity of a DNA-binding complex, highlighting intricate regulatory mechanisms involving these proteins. Both Bex1 and Bex2 are also expressed outside the central nervous system, particularly in the liver, and exhibit dynamic shuttling between the cytoplasm and nucleus. While Bex1′s precise role remains largely undefined, Bex1 coordinates internal cellular states with the ability of cells to respond to external signals, making Bex1 an important target for research in neurobiology and cellular signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Bex1/2 Antibody (D-6) References:
- Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. | Brown, AL. and Kay, GF. 1999. Hum Mol Genet. 8: 611-9. PMID: 10072429
- Trophectoderm-specific expression of the X-linked Bex1/Rex3 gene in preimplantation stage mouse embryos. | Williams, JW., et al. 2002. Mol Reprod Dev. 61: 281-7. PMID: 11835573
- Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. | Yang, QS., et al. 2002. Biochem Genet. 40: 1-12. PMID: 11989783
- Immunolocalization of Bex protein in the mouse brain and olfactory system. | Koo, JH., et al. 2005. J Comp Neurol. 487: 1-14. PMID: 15861462
- Characterization of the Bex gene family in humans, mice, and rats. | Alvarez, E., et al. 2005. Gene. 357: 18-28. PMID: 15958283
- Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. | Han, C., et al. 2005. Nucleic Acids Res. 33: 6555-65. PMID: 16314316
- Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. | Vilar, M., et al. 2006. EMBO J. 25: 1219-30. PMID: 16498402
- Analysis of optic nerve stroke by retinal Bex expression. | Bernstein, SL., et al. 2006. Mol Vis. 12: 147-55. PMID: 16541015
- Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. | Foltz, G., et al. 2006. Cancer Res. 66: 6665-74. PMID: 16818640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bex1/2 Antibody (D-6) | sc-376342 | 200 µg/ml | $322.00 | |||
Bex1/2 Antibody (D-6) AC | sc-376342 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Bex1/2 Antibody (D-6) HRP | sc-376342 HRP | 200 µg/ml | $322.00 | |||
Bex1/2 Antibody (D-6) FITC | sc-376342 FITC | 200 µg/ml | $336.00 | |||
Bex1/2 Antibody (D-6) PE | sc-376342 PE | 200 µg/ml | $349.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 488 | sc-376342 AF488 | 200 µg/ml | $364.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 546 | sc-376342 AF546 | 200 µg/ml | $364.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 594 | sc-376342 AF594 | 200 µg/ml | $364.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 647 | sc-376342 AF647 | 200 µg/ml | $364.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 680 | sc-376342 AF680 | 200 µg/ml | $364.00 | |||
Bex1/2 Antibody (D-6) Alexa Fluor® 790 | sc-376342 AF790 | 200 µg/ml | $364.00 |