beta-catenin Antibody (A-5): sc-393501
- beta-catenin Antibody (A-5) is a mouse monoclonal IgG2b κ, cited in 11 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 727-754 near the C-terminus of β-catenin of human origin
- recommended for detection of β-catenin of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- See beta-catenin (E-5): sc-7963 for beta-catenin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for beta-catenin Antibody (A-5) for WB and IHC(P) applications. These reagents are now offered in bundles with beta-catenin Antibody (A-5) (see ordering information below).
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β-catenin Antibody (A-5) is a mouse monoclonal IgG2b kappa light chain antibody engineered to detect β-catenin, also known as CTNNB1, a pivotal protein with a distinctive structure essential for cellular adhesion and signaling. β-catenin is characterized by armadillo repeat domains, which facilitate interactions with various proteins, including cadherins and transcription factors, thereby playing a crucial role in maintaining tissue structural integrity and regulating gene expression. The structural configuration enables binding to the intracellular cytoplasmic tail of E-cadherin, a process vital for forming and stabilizing adherens junctions that ensure proper cell-cell adhesion and tissue architecture. Additionally, nuclear translocation and interaction with transcription factors are integral to the Wnt signaling pathway, influencing cell proliferation, differentiation, and migration - processes fundamental to normal development and frequently implicated in cancer when dysregulated. Anti-β-catenin antibody (A-5) specifically targets an epitope between amino acids 727-754 near the C-terminus of human β-catenin, ensuring precise detection across multiple species, including mouse, rat, human, avian, equine, canine, bovine, and porcine. β-catenin monoclonal antibody (A-5) is validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), making this reagent versatile for diverse research needs. By enabling detailed studies of structural interactions and functional roles in both cell adhesion and signaling pathways, β-catenin (A-5) antibody is indispensable for researchers investigating molecular mechanisms underlying cellular communication, development, and oncogenesis. Anti-β-catenin antibody (A-5) ensures reliable performance in various experimental setups, facilitating advancements in understanding β-catenin′s functions in numerous biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
beta-catenin Antibody (A-5) | sc-393501 | 200 µg/ml | $322.00 | |||
beta-catenin Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-538233 | 200 µg Ab; 10 µg BP | $361.00 | |||
beta-catenin Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-535805 | 200 µg Ab; 40 µg BP | $361.00 | |||
beta-catenin Antibody (A-5): m-IgG2b BP-HRP Bundle | sc-549928 | 200 µg Ab; 10 µg BP | $361.00 | |||
beta-catenin (A-5) Neutralizing Peptide | sc-393501 P | 100 µg/0.5 ml | $69.00 |