β-casein Antibody (B-5): sc-393734

β-casein Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects β-casein in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-casein plays a vital role in the nutritional development of newborn mammals, particularly in human milk, where β-casein is one of the primary casein proteins. The unique structure of β-casein, characterized by a high degree of phosphorylation, enhances β-casein′s ability to bind calcium, which is essential for the formation of micelles that facilitate nutrient absorption in neonates. This calcium-binding capacity not only aids in digestion but also contributes to β-casein′s stability in the milk matrix, ensuring essential nutrients are delivered effectively during the critical early days of life. The expression of β-casein is tightly regulated by various transcription factors, including Stat5 and C/EBPβ, which respond to lactogenic hormones, highlighting the intricate control mechanisms that ensure proper synthesis. β-casein Antibody (B-5) serves as an invaluable tool for researchers studying milk protein dynamics, neonatal nutrition, and the regulatory pathways involved in lactation.

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β-casein Antibody (B-5) References:

1. Antibodies to bovine beta-casein in diabetes and other autoimmune diseases.  |  Monetini, L., et al. 2002. Horm Metab Res. 34: 455-9. PMID: 12198602
2. Gap junctions mediate STAT5-independent β-casein expression in CID-9 mammary epithelial cells.  |  Talhouk, RS., et al. 2011. Cell Commun Adhes. 18: 104-16. PMID: 22142338
3. Interaction of transglutaminase with adsorbed and spread films of β-casein and к-casein.  |  Ridout, MJ., et al. 2015. Colloids Surf B Biointerfaces. 128: 254-260. PMID: 25686794
4. Short communication: Tryptic β-casein hydrolysate modulates enteric nervous system development in primary culture.  |  Cossais, F., et al. 2017. J Dairy Sci. 100: 3396-3403. PMID: 28259395
5. An anticoagulant peptide from beta-casein: identification, structure and molecular mechanism.  |  Liu, H., et al. 2019. Food Funct. 10: 886-892. PMID: 30693925
6. Maillard induced glycation of β-casein for enhanced stability of the self-assembly micelles against acidic and calcium environment.  |  Li, M., et al. 2022. Food Chem. 387: 132914. PMID: 35421650
7. Rat beta casein cDNA: sequence analysis and evolutionary comparisons.  |  Blackburn, DE., et al. 1982. Nucleic Acids Res. 10: 2295-307. PMID: 6283475
8. Structure of the human beta-casein encoding gene.  |  Hansson, L., et al. 1994. Gene. 139: 193-9. PMID: 8112603
9. Immunogenicity of casein phosphopeptides derived from tryptic hydrolysis of beta-casein.  |  Heddleson, RA., et al. 1997. J Dairy Sci. 80: 1971-6. PMID: 9313137
10. Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules.  |  Chida, D., et al. 1998. Mol Endocrinol. 12: 1792-806. PMID: 9817603

The preferred β-casein antibody is β-casein Antibody (F20.14): sc-53189.