β-2-Microglobulin Antibody (S19.8): sc-32241
- β-2-Microglobulin Antibody (S19.8) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against B10.S spleen cells
- Anti-beta-2-Microglobulin Antibody (S19.8) is recommended for detection of β-2-Microglobulin of mouse, rat, human and primate origin by IF and FCM; may cross-react with mouse strains C57BL/6, C57BL/10, C57BR and C57L; not recommended for detection of A, AKR, BALB/c, C58, C3H, CBA, DBA/1, DBA/2, SJL, SWR, and 129 strains.
- Anti-beta-2-Microglobulin Antibody (S19.8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for β-2-Microglobulin Antibody (S19.8). These reagents are now offered in bundles with β-2-Microglobulin Antibody (S19.8) (see ordering information below).
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β-2-Microglobulin Antibody (S19.8) is a mouse monoclonal IgG2b kappa light chain antibody that detects β-2-Microglobulin in mouse, rat, human, and primate samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Anti-β-2-Microglobulin antibody (S19.8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. β-2-Microglobulin plays a crucial role in the immune system as a component of major histocompatibility complex (MHC) class I molecules, which are essential for presenting peptide antigens on the surface of cells to T cells, thereby facilitating immune responses. β-2-Microglobulin is located on the cell surface, where β-2-Microglobulin associates non-covalently with the heavy chain of MHC class I molecules, forming a stable complex that is vital for proper folding and expression of these molecules. This interaction is critical for the immune system′s ability to recognize and respond to infected or malignant cells. Notably, mice lacking β-2-Microglobulin exhibit a normal distribution of T cells but are unable to produce mature CD4-8+ T cells, leading to impaired cytotoxic T cell responses. The human β-2-Microglobulin gene is located on chromosome 15q21-q22.2 and encodes a 119 amino acid protein, with mutations in this gene being linked to the progression of malignant melanoma phenotypes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
β-2-Microglobulin Antibody (S19.8) References:
- Beta 2-microglobulin-associated amyloidoses. | Gejyo, F. and Arakawa, M. 1992. J Intern Med. 232: 531-2. PMID: 1474361
- Solution structure of beta(2)-microglobulin and insights into fibrillogenesis. | Esposito, G., et al. 2005. Biochim Biophys Acta. 1753: 76-84. PMID: 16081329
- Structure and metabolism of beta-2-microglobulin. | Revillard, JP. and Vincent, C. 1988. Contrib Nephrol. 62: 44-53. PMID: 3282797
- Serum beta 2 microglobulin in multiple myeloma. A critical review. | Bataille, R. and Grenier, J. 1987. Eur J Cancer Clin Oncol. 23: 1829-32. PMID: 3325293
- Beta 2 microglobulin correlates with oxidative stress in elderly. | Althubiti, M., et al. 2021. Exp Gerontol. 150: 111359. PMID: 33905876
- beta 2-Microglobulin: structure, function and significance. | Bernier, GM. 1980. Vox Sang. 38: 323-7. PMID: 6159720
- Beta-2-microglobulin review: its relevance in clinical oncology. | Cooper, EH. and Plesner, T. 1980. Med Pediatr Oncol. 8: 323-34. PMID: 6161299
- Beta 2-microglobulin in haematological malignancies. | . 1981. Br Med J (Clin Res Ed). 282: 1013. PMID: 6163499
- Beta 2-microglobulin in skin cancer. | Dahl, MV. 1981. J Am Acad Dermatol. 5: 698-9. PMID: 6172454
- Beta-2 microglobulin in renal disease. | Miyata, T., et al. 1998. J Am Soc Nephrol. 9: 1723-35. PMID: 9727382
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-2-Microglobulin Antibody (S19.8) | sc-32241 | 200 µg/ml | $316.00 | |||
β-2-Microglobulin Antibody (S19.8): m-IgG Fc BP-HRP Bundle | sc-525531 | 200 µg Ab; 10 µg BP | $354.00 | |||
β-2-Microglobulin Antibody (S19.8): m-IgG2b BP-HRP Bundle | sc-549573 | 200 µg Ab; 10 µg BP | $354.00 | |||
β-2-Microglobulin Antibody (S19.8) AC | sc-32241 AC | 500 µg/ml, 25% agarose | $416.00 | |||
β-2-Microglobulin Antibody (S19.8) HRP | sc-32241 HRP | 200 µg/ml | $316.00 | |||
β-2-Microglobulin Antibody (S19.8) FITC | sc-32241 FITC | 200 µg/ml | $330.00 | |||
β-2-Microglobulin Antibody (S19.8) PE | sc-32241 PE | 200 µg/ml | $343.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 488 | sc-32241 AF488 | 200 µg/ml | $357.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 546 | sc-32241 AF546 | 200 µg/ml | $357.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 594 | sc-32241 AF594 | 200 µg/ml | $357.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 647 | sc-32241 AF647 | 200 µg/ml | $357.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 680 | sc-32241 AF680 | 200 µg/ml | $357.00 | |||
β-2-Microglobulin Antibody (S19.8) Alexa Fluor® 790 | sc-32241 AF790 | 200 µg/ml | $357.00 |