β-2-Microglobulin Antibody (BBM.1): sc-13565

β-2-Microglobulin Antibody (BBM.1) is a mouse monoclonal IgG2b kappa light chain antibody that detects β-2-Microglobulin protein of mouse, rat, human, and primate origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-β-2-Microglobulin antibody (BBM.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β-2-Microglobulin plays a crucial role in the immune system as a component of major histocompatibility complex (MHC) class I molecules, which are essential for presenting peptide antigens on the surface of cells to T cells. This presentation is vital for the immune response, as β-2-Microglobulin allows the immune system to recognize and eliminate infected or malignant cells. β-2-Microglobulin′s structure includes a non-covalent association with the alpha heavy chain of MHC class I, forming an immunoglobulin domain-like structure critical for proper folding and expression of these molecules. Mice lacking β-2-Microglobulin exhibit a normal distribution of T cells but are unable to produce mature CD4-8+ T cells, leading to defects in T cell-mediated cytotoxicity. The human β-2-Microglobulin gene is located on chromosome 15q21-q22.2 and encodes a 119 amino acid protein, with mutations in this gene being linked to the progression of malignant melanoma phenotypes.

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β-2-Microglobulin Antibody (BBM.1) References:

1. Beta(2)-microglobulin and bone cell metabolism.  |  Balint, E. and Sprague, SM. 2001. Nephrol Dial Transplant. 16: 1108-11. PMID: 11390706
2. A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells.  |  Drbal, K., et al. 2001. Blood. 98: 1561-6. PMID: 11520808
3. T cell precursor migration towards beta 2-microglobulin is involved in thymus colonization of chicken embryos.  |  Dunon, D., et al. 1990. EMBO J. 9: 3315-22. PMID: 1698612
4. Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.  |  Zijlstra, M., et al. 1990. Nature. 344: 742-6. PMID: 2139497
5. The immune-related role of beta-2-microglobulin in melanoma.  |  Wang, C., et al. 2022. Front Oncol. 12: 944722. PMID: 36046045
6. Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity.  |  Maya-Martinez, R., et al. 2022. J Biol Chem. 298: 102659. PMID: 36328246
7. Design of Beta-2 Microglobulin Adsorbent Protein Nanoparticles.  |  Miller, JE., et al. 2023. Biomolecules. 13: PMID: 37509158
8. Conformational changes induced in the MHC class I molecule by peptide and beta 2-microglobulin.  |  Solheim, JC., et al. 1995. Immunol Res. 14: 200-17. PMID: 8778210
9. Mechanisms of MHC class I--restricted antigen processing.  |  Pamer, E. and Cresswell, P. 1998. Annu Rev Immunol. 16: 323-58. PMID: 9597133
10. beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.  |  Hicklin, DJ., et al. 1998. J Clin Invest. 101: 2720-9. PMID: 9637706
11. IFN-gamma induces coordinate expression of MHC class I-mediated antigen presentation machinery molecules in adult mouse Schwann cells.  |  Tsuyuki, Y., et al. 1998. Neuroreport. 9: 2071-5. PMID: 9674595
12. Isolation and characterization of chicken and turkey beta 2-microglobulin.  |  Skjødt, K., et al. 1986. Mol Immunol. 23: 1301-9. PMID: 3547090

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-2-Microglobulin Antibody (BBM.1) has 34 citations in a variety of scientific publications.

Primary antibodies like Anti-β-2-Microglobulin Antibody (BBM.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-2-Microglobulin Antibody (BBM.1) Specifications

Alternate Product Name: β-2-Microglobulin

Product Clone Name: BBM.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: β-2-Microglobulin

Epitope Species: human

Product Reactivity/Detection: β-2-Microglobulin

Species Reactivity/Detection: mouse, rat, human, primate

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 34 citations in various scientific publications

Available Conjugates/Forms for β-2-Microglobulin Antibody (BBM.1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred β-2-Microglobulin antibody is β-2-Microglobulin Antibody (S19.8): sc-32241.