Date published: 2025-9-8
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β-2-Microglobulin Antibody (BBM.1) - Western Blotting - Image 61980
β-2-微球蛋白 (BBM. 1): sc-13565. 对 HL-60 全细胞裂解液中 β-2-Microglobulin 的表达进行 Western 印迹分析.
β-2-微球蛋白 (BBM. 1): sc-13565. 对 HL-60 全细胞裂解液中 β-2-Microglobulin 的表达进行 Western 印迹分析.

β-2-Microglobulin 抗体 (BBM.1): sc-13565

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说明书
  • beta-2-Microglobulin 抗体 BBM.1 是小鼠单克隆 IgG2b κ，β-2-Microglobulin抗体, 在34篇文献中引用，规格为200 µg/ml
  • 针对MOLT-4 human T细胞系
  • beta-2-Microglobulin 抗体 (BBM.1) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat, human 和primate 来源的 β-2-Microglobulin
  • 抗beta-2-Microglobulin抗体（BBM.1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取β-2-Microglobulin (BBM.1): sc-13565的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRP 是β-2-Microglobulin 抗体 (BBM.1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与β-2-Microglobulin 抗体 (BBM.1) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

β-2-微球蛋白抗体（BBM.1）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠、人类和灵长类动物的β-2-微球蛋白。抗β-2-微球蛋白抗体（BBM.1）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。β-2-微球蛋白作为主要组织相容性复合物（MHC）I类分子的组成部分，在免疫系统中发挥着至关重要的作用，而MHC I类分子对于将肽抗原呈递到T细胞表面至关重要。这种呈现对于免疫反应至关重要，因为β-2-微球蛋白使免疫系统能够识别并消灭受感染或恶性的细胞。β-2-微球蛋白的结构包括与MHC I类α重链的非共价结合，形成免疫球蛋白结构域样结构，对于这些分子的正确折叠和表达至关重要。缺乏β-2-微球蛋白的小鼠T细胞分布正常，但无法产生成熟的CD4-8+ T细胞，导致T细胞介导的细胞毒性缺陷。人类β-2-微球蛋白基因位于15q21-q22.2染色体上，编码一种119个氨基酸的蛋白质，该基因的突变与恶性黑色素瘤表型的进展有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

β-2-Microglobulin 抗体 (BBM.1) 参考文献:

  1. β（2）-微球蛋白与骨细胞代谢  |  Balint, E. and Sprague, SM. 2001. Nephrol Dial Transplant. 16: 1108-11. PMID: 11390706
  2. 游离 CD18（白细胞整合素的共同链）的蛋白水解截短形式是活化髓系细胞的新标记。  |  Drbal, K., et al. 2001. Blood. 98: 1561-6. PMID: 11520808
  3. T 细胞前体向β2-微球蛋白的迁移参与了鸡胚胸腺的定植。  |  Dunon, D., et al. 1990. EMBO J. 9: 3315-22. PMID: 1698612
  4. 缺乏β2-微球蛋白的小鼠缺乏CD4-8+细胞溶解性T细胞。  |  Zijlstra, M., et al. 1990. Nature. 344: 742-6. PMID: 2139497
  5. beta-2 微球蛋白在黑色素瘤中的免疫相关作用。  |  Wang, C., et al. 2022. Front Oncol. 12: 944722. PMID: 36046045
  6. D76N-β2-微球蛋白的二聚体具有强大的抗淀粉样蛋白聚集活性。  |  Maya-Martinez, R., et al. 2022. J Biol Chem. 298: 102659. PMID: 36328246
  7. 设计 Beta-2 微球蛋白吸附蛋白纳米颗粒  |  Miller, JE., et al. 2023. Biomolecules. 13: PMID: 37509158
  8. 肽和β2-微球蛋白诱导的 MHC I 类分子构象变化。  |  Solheim, JC., et al. 1995. Immunol Res. 14: 200-17. PMID: 8778210
  9. MHC I 类受限抗原处理机制。  |  Pamer, E. and Cresswell, P. 1998. Annu Rev Immunol. 16: 323-58. PMID: 9597133
  10. 黑色素瘤中的β2-微球蛋白突变, HLA I 类抗原丢失和肿瘤进展。  |  Hicklin, DJ., et al. 1998. J Clin Invest. 101: 2720-9. PMID: 9637706
  11. IFN-gamma 可诱导成年小鼠许旺细胞协调表达 MHC I 类介导的抗原递呈机制分子。  |  Tsuyuki, Y., et al. 1998. Neuroreport. 9: 2071-5. PMID: 9674595
  12. 鸡和火鸡 beta 2-微球蛋白的分离和特征。  |  Skjødt, K., et al. 1986. Mol Immunol. 23: 1301-9. PMID: 3547090

订购信息

产品名称产品编号规格价格数量收藏夹

β-2-Microglobulin 抗体 (BBM.1)

sc-13565
200 µg/ml
$316.00

β-2-Microglobulin (BBM.1): m-IgG2b BP-HRP 套装

sc-548646
200 µg Ab; 10 µg BP
$354.00

β-2-Microglobulin 抗体 (BBM.1) AC

sc-13565 AC
500 µg/ml, 25% agarose
$416.00

β-2-Microglobulin 抗体 (BBM.1) HRP

sc-13565 HRP
200 µg/ml
$316.00

β-2-Microglobulin 抗体 (BBM.1) FITC

sc-13565 FITC
200 µg/ml
$330.00

β-2-Microglobulin 抗体 (BBM.1) PE

sc-13565 PE
200 µg/ml
$343.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 488

sc-13565 AF488
200 µg/ml
$357.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 546

sc-13565 AF546
200 µg/ml
$357.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 594

sc-13565 AF594
200 µg/ml
$357.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 647

sc-13565 AF647
200 µg/ml
$357.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 680

sc-13565 AF680
200 µg/ml
$357.00

β-2-Microglobulin 抗体 (BBM.1) Alexa Fluor® 790

sc-13565 AF790
200 µg/ml
$357.00

Does this antibody work well in ELISA to detect mouse B2m? If so, at what concentration? because my first tests are not conclusive. Thank you!

Asked by: AP2R
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

Is there a CoA of the lot F2118? Thank you!

Asked by: martaoxford
Thank you for your question. We do not provide lot-specific Certificates of Analysis (CoA's) for our research antibodies. Please contact our Technical Service Department for further support.
Answered by: Technical Support
Date published: 2019-01-17

What is the recommended secondary for this antibody?

Asked by: AbPolly
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 9
Date published: 2017-01-12

Can this antibody be used with bovine samples?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 9
Date published: 2017-01-12
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Rated 5 out of 5 by from Tested on HFFF by FACSThis antibody was tested on HFFF cells by FACS and gave a very strong signal, even at dilution 1:100
Date published: 2018-11-19
Rated 5 out of 5 by from Works very wellI applied this antibody for immunofluorescence. It works very well.
Date published: 2018-06-27
Rated 5 out of 5 by from Superb!!Great western blot data; also strong product for IF and IHC staining applications
Date published: 2017-01-31
Rated 5 out of 5 by from Great reactivity.This antibody is cross-reactive with standard mouse, rat and human, but it also reactive with primate samples. It works well for blotting or staining and has been cited nearly 30 times.
Date published: 2017-01-30
Rated 5 out of 5 by from Strong pulldown in IP in human HeLaStrong pulldown in IP in human HeLa, T1, U937, HLA-A2.1-expressing renal carcinoma MZ1851 RC cells. -SCBT QC
Date published: 2015-07-18
Rated 5 out of 5 by from Good staining in IF in rhesus peripheralGood staining in IF in rhesus peripheral blood mononuclear cells. -SCBT Publication Review
Date published: 2015-06-27
Rated 5 out of 5 by from Published for flow cytometry in human K562 cellsPublished for flow cytometry in human K562 cells. -SCBT Publication Review
Date published: 2015-06-27
Rated 5 out of 5 by from Works fine in WBWorks fine in WB.
Date published: 2015-03-25
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β-2-Microglobulin 抗体 (BBM.1) is rated 5.0 out of 5 by 13.
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