β-2-Microglobulin Antibody (G-10): sc-46697

β-2-Microglobulin Antibody (G-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects β-2-Microglobulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). β-2-Microglobulin (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β-2-Microglobulin plays a crucial role in the immune system as a component of major histocompatibility complex (MHC) class I molecules, which are essential for presenting antigens on the surface of cells. This presentation is vital for the recognition of infected or malignant cells by CD8+ cytotoxic T lymphocytes, thereby facilitating an effective immune response. β-2-Microglobulin is located on the cell surface, where β-2-Microglobulin associates non-covalently with the heavy chain of MHC class I molecules, contributing to their stability and proper folding. Notably, the absence of β-2-Microglobulin leads to a lack of mature CD4-8+ T cells, highlighting β-2-Microglobulin′s importance in T cell development and function. The human β-2-Microglobulin gene is located on chromosome 15q21-q22.2 and encodes a 119 amino acid protein, with mutations in this gene being linked to the progression of malignant melanoma phenotypes.

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β-2-Microglobulin Antibody (G-10) References:

1. Colitis in HLA-B27/beta 2 microglobulin transgenic rats.  |  Sartor, RB. 2000. Int Rev Immunol. 19: 39-50. PMID: 10723676
2. Localization of beta 2-microglobulin in the term villous syncytiotrophoblast.  |  Leitner, K., et al. 2002. Histochem Cell Biol. 117: 187-93. PMID: 11935295
3. Beta-2-microglobulin handling in dialysis.  |  Klinke, B., et al. 1989. Contrib Nephrol. 74: 139-46. PMID: 2702131
4. Beta 2-microglobulin kinetics during haemofiltration.  |  Floege, J., et al. 1988. Nephrol Dial Transplant. 3: 784-9. PMID: 3147420
5. Structural Heterogeneity in the Preamyloid Oligomers of β-2-Microglobulin.  |  Marcinko, TM., et al. 2020. J Mol Biol. 432: 396-409. PMID: 31711963
6. Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases.  |  Mahe, K., et al. 2021. Int J Hematol. 114: 222-227. PMID: 34021850
7. Interfacial Dynamics and Growth Modes of β2-Microglobulin Dimers.  |  Oliveira, NFB., et al. 2023. J Chem Inf Model. 63: 4447-4457. PMID: 37132512
8. Serum beta 2-microglobulin in chronic liver diseases.  |  Nakamura, S., et al. 1981. Tohoku J Exp Med. 134: 221-2. PMID: 6171912
9. Effects of alpha-interferon on serum beta-2-microglobulin.  |  Remes, K., et al. 1996. Leuk Lymphoma. 21: 233-8. PMID: 8726404
10. beta 2-Microglobulin: methods and clinical applications.  |  Poulik, MD., et al. 1979. CRC Crit Rev Clin Lab Sci. 10: 225-45. PMID: 89022

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-2-Microglobulin Antibody (G-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-β-2-Microglobulin Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-2-Microglobulin Antibody (G-10) Specifications

Alternate Product Name: β-2-Microglobulin

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-119

Epitope Target: β-2-Microglobulin

Epitope Species: human

Product Reactivity/Detection: β-2-Microglobulin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for β-2-Microglobulin Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred β-2-Microglobulin antibody is β-2-Microglobulin Antibody (BBM.1): sc-13565.