Bag-1 Antibody (A-8): sc-515535

Bag-1 Antibody (A-8) is a mouse monoclonal IgG2b antibody that detects Bag-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Bag-1 is a critical regulator of apoptosis, functioning as a Bcl-2-binding protein that enhances the protective effects of Bcl-2 against cell death. This interaction suggests that Bag-1 may play a significant role in determining cell survival in various physiological and pathological contexts, including cancer. By stabilizing Bcl-2, Bag-1 can influence the balance between pro-apoptotic and anti-apoptotic signals, thereby impacting cellular responses to stress and therapeutic interventions. The ability of Bag-1 to modulate apoptosis highlights its potential as a target for therapeutic strategies aimed at manipulating cell death pathways in diseases where apoptosis is dysregulated. anti-Bag-1 antibody (A-8) serves as an essential tool for researchers investigating the intricate mechanisms of apoptosis and cell survival.

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Bag-1 Antibody (A-8) References:

1. Differential expression of antiapoptotic gene BAG-1 in human breast normal and cancer cell lines and tissues.  |  Yang, X., et al. 1999. Clin Cancer Res. 5: 1816-22. PMID: 10430086
2. Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis.  |  Sourisseau, T., et al. 2001. J Cell Sci. 114: 1409-16. PMID: 11257006
3. The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock.  |  Coldwell, MJ., et al. 2001. Oncogene. 20: 4095-100. PMID: 11494137
4. BAG-1 immunostaining and survival in early breast cancer.  |  Cutress, RI., et al. 2001. J Clin Oncol. 19: 3706-7. PMID: 11504752
5. BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.  |  Townsend, PA., et al. 2002. J Pathol. 197: 51-9. PMID: 12081204
6. BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian cancer cells.  |  Pagé, V., et al. 2005. Biochem Biophys Res Commun. 328: 874-84. PMID: 15707960
7. Hemagglutinating virus of Japan-artificial viral envelope liposome-mediated cotransfer of bag-1 and bcl-2 genes protects hepatic cells against ischemic injury through BAG-1-assisted preferential enhancement of bcl-2 protein expression.  |  Yanada, S., et al. 2005. Hum Gene Ther. 16: 627-33. PMID: 15916487
8. BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells.  |  Crabb, SJ., et al. 2008. Oncol Rep. 19: 689-96. PMID: 18288403
9. Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer.  |  Nadler, Y., et al. 2008. Breast Cancer Res. 10: R35. PMID: 18430249
10. BAG-1 is preferentially expressed in neuronal precursor cells of the adult mouse brain and regulates their proliferation in vitro.  |  Elliott, E. and Ginzburg, I. 2009. FEBS Lett. 583: 229-34. PMID: 19084526

The preferred Bag-1 antibody is Bag-1 Antibody (3.10G3E2): sc-56003.