BAFF-R Antibody (H-1): sc-365410

BAFF-R Antibody (H-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects BAFF-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-BAFF-R antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BAFF-R, a member of the tumor necrosis factor (TNF) receptor family, plays a critical role in B cell development and survival by mediating signals from TNF cytokine family member TALL-1, also known as BAFF. This type II membrane protein is primarily located on B cell surfaces, where BAFF-R is essential for selecting transitional B cells into the mature B cell pool, thereby influencing immune response. The gene encoding human BAFF-R is located on chromosome 22q13.1-q13.31 and shows high expression in spleen and lymph nodes, with lower levels in peripheral blood leukocytes and thymus. Understanding BAFF-R function and location remains vital, as BAFF-R signaling pathways are implicated in various autoimmune diseases and lymphoproliferative disorders, making BAFF-R a significant target for therapeutic interventions.

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BAFF-R Antibody (H-1) References:

1. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase.  |  Mukhopadhyay, A., et al. 1999. J Biol Chem. 274: 15978-81. PMID: 10347144
2. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.  |  Schneider, P., et al. 1999. J Exp Med. 189: 1747-56. PMID: 10359578
3. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.  |  Moore, PA., et al. 1999. Science. 285: 260-3. PMID: 10398604
4. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.  |  Thompson, JS., et al. 2001. Science. 293: 2108-11. PMID: 11509692
5. Immunology. Long live the mature B cell--a baffling mystery resolved.  |  Waldschmidt, TJ. and Noelle, RJ. 2001. Science. 293: 2012-3. PMID: 11557866
6. Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice.  |  Kim, SS., et al. 2011. J Neurol Sci. 306: 9-15. PMID: 21529843
7. BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report.  |  Sage, AP., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 1573-6. PMID: 22426131
8. The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.  |  Saulep-Easton, D., et al. 2016. Leukemia. 30: 163-72. PMID: 26139429
9. Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction.  |  Sharma, A., et al. 2016. Clin Immunol. 164: 85-94. PMID: 26826598
10. BAFF upregulates CD28/B7 and CD40/CD154 expression and promotes mouse T and B cell interaction in vitro via BAFF receptor.  |  Zhang, F., et al. 2016. Acta Pharmacol Sin. 37: 1101-9. PMID: 27180986
11. Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.  |  Bloom, DD., et al. 2018. J Immunother. 41: 213-223. PMID: 29309290
12. Elevated expression of BAFF receptor, BR3, on monocytes correlates with B cell activation and clinical features of patients with primary Sjögren's syndrome.  |  Yoshimoto, K., et al. 2020. Arthritis Res Ther. 22: 157. PMID: 32576236

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAFF-R Antibody (H-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BAFF-R Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAFF-R Antibody (H-1) Specifications

Alternate Product Name: BAFF-R

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 22-184

Epitope Target: BAFF-R

Epitope Species: human

Product Reactivity/Detection: BAFF-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BAFF-R Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin