BAF60a Antibody (23): sc-135843

BAF60a Antibody (23) is a mouse monoclonal IgG2a antibody that detects BAF60a of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-BAF60a antibody (23) is available as the non-conjugated form. BAF60a, also known as BRG1-associated factor 60A or SMARCD1, is a 476 amino acid protein that plays a crucial role in chromatin remodeling by acting as a component of the BAF complex. BAF60a (23) monoclonal antibody is predominantly localized in the nucleus, where BAF60a interacts with various other proteins to facilitate the dynamic restructuring of chromatin, which is essential for regulating gene expression. BAF60a (23) antibody recognizes a protein involved in transcriptional activity mediated by vitamin D, serving as a critical link between the vitamin D receptor and SWI/SNF chromatin remodeling complexes. Multiple isoforms of BAF60a, resulting from alternative splicing, add another layer of complexity to BAF60a function and regulation, making BAF60a a significant focus of study in understanding cellular processes and gene regulation.

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BAF60a Antibody (23) References:

1. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.  |  Phelan, ML., et al. 1999. Mol Cell. 3: 247-53. PMID: 10078207
2. Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers.  |  Ito, T., et al. 2001. J Biol Chem. 276: 2852-7. PMID: 11053448
3. The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.  |  Xue, Y., et al. 2000. Proc Natl Acad Sci U S A. 97: 13015-20. PMID: 11078522
4. Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.  |  Nie, Z., et al. 2003. Mol Cell Biol. 23: 2942-52. PMID: 12665591
5. The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.  |  Kitagawa, H., et al. 2003. Cell. 113: 905-17. PMID: 12837248
6. BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.  |  Hsiao, PW., et al. 2003. Mol Cell Biol. 23: 6210-20. PMID: 12917342
7. Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism.  |  Zhang, P., et al. 2016. Nutr Metab (Lond). 13: 30. PMID: 27127533
8. NMR spectroscopy uncovers direct interaction between BAF60A and p53.  |  Han, J., et al. 2021. Biochem Biophys Res Commun. 534: 815-821. PMID: 33168186
9. BAF60a Deficiency in Macrophage Promotes Diet-Induced Obesity and Metabolic Inflammation.  |  Kong, Q., et al. 2022. Diabetes. 71: 2136-2152. PMID: 35822944
10. Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis.  |  Zhao, Y., et al. 2023. Cell Rep. 42: 113171. PMID: 37768825
11. Diversity and specialization of mammalian SWI/SNF complexes.  |  Wang, W., et al. 1996. Genes Dev. 10: 2117-30. PMID: 8804307
12. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.  |  Ring, HZ., et al. 1998. Genomics. 51: 140-3. PMID: 9693044

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAF60a Antibody (23) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-BAF60a Antibody (23) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAF60a Antibody (23) Specifications

Alternate Product Name: BAF60a

Product Clone Name: 23

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 1-91

Epitope Target: BAF60a

Epitope Species: mouse

Product Reactivity/Detection: BAF60a

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for BAF60a Antibody (23): N/A

The preferred BAF60a antibody is BAF60a Antibody (A-11): sc-514400.