BACH1 Antibody (F-9): sc-271211

BACH1 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects BACH1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-BACH1 antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BACH1 plays a crucial role in regulating gene expression as a transcription factor, particularly in response to oxidative stress and heme levels, which is vital for cellular defense mechanisms and maintaining homeostasis. BACH1 functions by forming heterodimers with small Maf proteins, such as MafK, MafF, and MafG, allowing binding to specific DNA sequences and modulating transcription of target genes. BACH1′s ability to act as both a transcriptional repressor and activator, depending on dimerization partners, underscores importance in various biological processes, including hematopoiesis and immune response. BACH1′s wide expression across different tissues highlights potential involvement in diverse physiological and pathological conditions.

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BACH1 Antibody (F-9) References:

1. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.  |  Kobayashi, A., et al. 2000. Mol Cell Biol. 20: 1733-46. PMID: 10669750
2. Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.  |  Hoshino, H., et al. 2000. J Biol Chem. 275: 15370-6. PMID: 10809773
3. Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15.  |  Sasaki, S., et al. 2000. Oncogene. 19: 3739-49. PMID: 10949928
4. Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform.  |  Kanezaki, R., et al. 2001. J Biol Chem. 276: 7278-84. PMID: 11069897
5. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.  |  Lee, J., et al. 2019. Nature. 568: 254-258. PMID: 30842661
6. Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal.  |  Nishizawa, H., et al. 2023. FEBS J. 290: 1688-1704. PMID: 35107212
7. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.  |  Xie, X., et al. 2023. Cell Death Dis. 14: 48. PMID: 36670112
8. FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.  |  Zhu, XN., et al. 2023. J Hematol Oncol. 16: 9. PMID: 36774506
9. BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.  |  Guo, J., et al. 2023. Nucleic Acids Res. 51: 4284-4301. PMID: 36864760
10. Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.  |  Zhang, L., et al. 2023. J Exp Clin Cancer Res. 42: 296. PMID: 37946265
11. Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy.  |  Hu, D., et al. 2024. Biomark Res. 12: 21. PMID: 38321558
12. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.  |  Oyake, T., et al. 1996. Mol Cell Biol. 16: 6083-95. PMID: 8887638

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BACH1 Antibody (F-9) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-BACH1 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BACH1 Antibody (F-9) Specifications

Alternate Product Name: Transcription Factor BACH1

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 591-720

Epitope Target: BACH1

Epitope Species: human

Product Reactivity/Detection: BACH1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for BACH1 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred BACH1 antibody is BACH1 Antibody (L-25): sc-100995.