BACH1 Antibody (L-25): sc-100995

BACH1 Antibody (L-25) is a mouse monoclonal IgG2a kappa light chain antibody that detects BACH1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-BACH1 antibody (L-25) is available in a non-conjugated form, allowing for versatile experimental use. BACH1, a member of the BTB/POZ-basic region leucine zipper (bZip) family, plays a crucial role in regulating gene expression by acting as a transcription factor. BACH1 is particularly important in the cellular response to oxidative stress, as BACH1 can repress the expression of antioxidant genes when bound to Maf proteins. BACH1′s ability to form heterodimers with other proteins, such as MafK, allows BACH1 to modulate transcriptional activity, which is vital for maintaining cellular homeostasis and responding to environmental changes. Understanding BACH1 function is essential, as dysregulation of BACH1 has been implicated in various diseases, including cancer and cardiovascular disorders. BACH1 monoclonal antibody (L-25) specificity makes this antibody an invaluable tool for researchers studying BACH1′s role in these critical biological processes.

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BACH1 Antibody (L-25) References:

1. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells.  |  Wei, X., et al. 2019. Sci Adv. 5: eaau7887. PMID: 30891497
2. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.  |  Lignitto, L., et al. 2019. Cell. 178: 316-329.e18. PMID: 31257023
3. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.  |  Wiel, C., et al. 2019. Cell. 178: 330-345.e22. PMID: 31257027
4. A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism.  |  Padilla, J. and Lee, J. 2021. Cells. 10: PMID: 33809182
5. Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation.  |  Jia, M., et al. 2022. Circ Res. 130: 1038-1055. PMID: 35196865
6. Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway.  |  Wei, X., et al. 2023. Cardiovasc Res. 119: 1842-1855. PMID: 37279500
7. Antioxidants stimulate BACH1-dependent tumor angiogenesis.  |  Wang, T., et al. 2023. J Clin Invest. 133: PMID: 37651203
8. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.  |  Amaral, EP., et al. 2024. Nat Microbiol. 9: 120-135. PMID: 38066332
9. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.  |  Wang, Y., et al. 2024. Dev Cell. 59: 108-124.e7. PMID: 38101413
10. BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.  |  Jin, J., et al. 2023. Nat Commun. 14: 8428. PMID: 38129407

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BACH1 Antibody (L-25) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BACH1 Antibody (L-25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BACH1 Antibody (L-25) Specifications

Alternate Product Name: Transcription Factor BACH1

Product Clone Name: L-25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 396-493

Epitope Target: BACH1

Epitope Species: human

Product Reactivity/Detection: BACH1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BACH1 Antibody (L-25): N/A

The preferred BACH1 antibody is BACH1 Antibody (F-9): sc-271211.