BACE Antibody (H-10): sc-365947
- BACE Antibody (H-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 419-501 of BACE of mouse origin
- recommended for detection of BACE of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See BACE (61-3E7): sc-33711 for BACE antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BACE Antibody (H-10) for WB and IHC(P) applications. These reagents are now offered in bundles with BACE Antibody (H-10) (see ordering information below).
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BACE Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects BACE in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BACE, or beta-site amyloid precursor protein cleaving enzyme, plays a crucial role in the pathogenesis of Alzheimer′s disease by facilitating the cleavage of the amyloid precursor protein (APP) to produce amyloid beta-peptide (Aβ), a key component of amyloid plaques found in the brains of affected individuals. BACE (H-10) antibody reveals localization within the Golgi apparatus and endosomes, underscoring BACE′s involvement in the intracellular processing of APP and subsequent generation of Aβ. This spatial distribution helps understand the mechanisms of amyloid plaque formation and Alzheimer′s disease progression, making BACE a critical target for therapeutic intervention and research. BACE (H-10) monoclonal antibody serves as an invaluable tool for researchers investigating molecular pathways of Alzheimer′s disease and the role of amyloid beta in neurodegeneration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BACE Antibody (H-10) References:
- Beta-secretase (BACE) as a drug target for Alzheimer's disease. | Vassar, R. 2002. Adv Drug Deliv Rev. 54: 1589-602. PMID: 12453676
- Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors. | Wang, YS., et al. 2010. J Med Chem. 53: 942-50. PMID: 20043700
- Dynamin 1 regulates amyloid generation through modulation of BACE-1. | Zhu, L., et al. 2012. PLoS One. 7: e45033. PMID: 23024787
- Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. | Das, U., et al. 2016. Nat Neurosci. 19: 55-64. PMID: 26642089
- Exercise decreases BACE and APP levels in the hippocampus of a rat model of Alzheimer's disease. | Alkadhi, KA. and Dao, AT. 2018. Mol Cell Neurosci. 86: 25-29. PMID: 29128320
- Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking. | Paumier, JM., et al. 2019. FASEB J. 33: 2910-2927. PMID: 30332299
- BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease. | Maia, MA. and Sousa, E. 2019. Pharmaceuticals (Basel). 12: PMID: 30893882
- Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. | McKinzie, DL., et al. 2021. J Med Chem. 64: 8076-8100. PMID: 34081466
- Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer's treatment. | Jabir, NR., et al. 2021. Ann Med. 53: 2332-2344. PMID: 34889159
- Structure-Based Virtual Screening and Biological Characterization of Novel BACE-1 and Amyloid-β Aggregation Inhibitors. | Sharma, A., et al. 2024. ChemMedChem. e202400685. PMID: 39644140
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BACE Antibody (H-10) | sc-365947 | 200 µg/ml | $322.00 | |||
BACE Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-537856 | 200 µg Ab; 10 µg BP | $361.00 | |||
BACE Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-535283 | 200 µg Ab; 40 µg BP | $361.00 | |||
BACE Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-545407 | 200 µg Ab; 20 µg BP | $361.00 |