ATE1 Antibody (G-6): sc-398805
- ATE1 Antibody (G-6) is a mouse monoclonal IgG2b κ ATE1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 244-269 within an internal region of ATE1 of human origin
- ATE1 Antibody (G-6) is recommended for detection of ATE1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ATE1 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ATE1 Antibody (G-6) for WB applications. These reagents are now offered in bundles with ATE1 Antibody (G-6) (see ordering information below).
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SEE ALSO...
ATE1 Antibody (G-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects ATE1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATE1 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Arginyl-tRNA-protein transferase (ATE1), also known as arginyltransferase 1, is a crucial enzyme belonging to the R-transferase family, responsible for the posttranslational modification of proteins through the addition of arginine. This modification is essential for the recognition and subsequent degradation of proteins via the ubiquitin-proteasome pathway, particularly for substrates containing aspartate, glutamate, or cysteine at their N-termini. The ability of ATE1 to arginylate proteins not only influences their stability but also plays a significant role in various cellular processes, including cell signaling and apoptosis. ATE1 is a 518 amino acid protein that can exist in two distinct isoforms due to alternative splicing, and is primarily localized in the cytoplasm and nucleus, highlighting its importance in cellular function and regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ATE1 Antibody (G-6) References:
- An essential role of N-terminal arginylation in cardiovascular development. | Kwon, YT., et al. 2002. Science. 297: 96-9. PMID: 12098698
- Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. | Rai, R. and Kashina, A. 2005. Proc Natl Acad Sci U S A. 102: 10123-8. PMID: 16002466
- RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. | Lee, MJ., et al. 2005. Proc Natl Acad Sci U S A. 102: 15030-5. PMID: 16217033
- The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. | Hu, RG., et al. 2005. Nature. 437: 981-6. PMID: 16222293
- Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. | Kwon, YT., et al. 1999. Mol Cell Biol. 19: 182-93. PMID: 9858543
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ATE1 Antibody (G-6) | sc-398805 | 200 µg/ml | $322.00 | |||
ATE1 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-530936 | 200 µg Ab; 10 µg BP | $361.00 | |||
ATE1 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-524495 | 200 µg Ab, 40 µg BP | $361.00 | |||
ATE1 Antibody (G-6): m-IgG2b BP-HRP Bundle | sc-550239 | 200 µg Ab; 10 µg BP | $361.00 | |||
ATE1 Antibody (G-6) AC | sc-398805 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ATE1 Antibody (G-6) HRP | sc-398805 HRP | 200 µg/ml | $322.00 | |||
ATE1 Antibody (G-6) FITC | sc-398805 FITC | 200 µg/ml | $336.00 | |||
ATE1 Antibody (G-6) PE | sc-398805 PE | 200 µg/ml | $349.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 488 | sc-398805 AF488 | 200 µg/ml | $364.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 546 | sc-398805 AF546 | 200 µg/ml | $364.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 594 | sc-398805 AF594 | 200 µg/ml | $364.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 647 | sc-398805 AF647 | 200 µg/ml | $364.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 680 | sc-398805 AF680 | 200 µg/ml | $364.00 | |||
ATE1 Antibody (G-6) Alexa Fluor® 790 | sc-398805 AF790 | 200 µg/ml | $364.00 | |||
ATE1 (G-6) Neutralizing Peptide | sc-398805 P | 100 µg/0.5 ml | $69.00 |