ATE1 Inhibitors
ATE1 inhibitors are a class of compounds that target the enzymatic activity of arginyltransferase 1 (ATE1), an enzyme responsible for the post-translational modification of proteins through the addition of arginine residues to their N-terminal regions. This process, known as arginylation, is a key part of the N-end rule pathway, which governs protein stability and degradation. By modulating the degradation of specific proteins, ATE1 plays a central role in regulating various cellular processes, including protein quality control, stress responses, and the maintenance of cellular homeostasis. ATE1 inhibitors, therefore, work by blocking this enzymatic activity, which in turn prevents the arginylation of proteins, leading to changes in the cellular proteome and the balance of protein degradation.
Structurally, ATE1 inhibitors may interact with the active site of the enzyme, interfering with its ability to bind to substrate proteins or the charged tRNA(Arg), which provides the arginine residue necessary for transfer. These inhibitors could potentially affect a wide range of cellular pathways that rely on protein turnover and post-translational modifications, making them of interest for studying proteostasis mechanisms. Research into ATE1 inhibitors typically focuses on understanding their molecular interactions, specificity, and how these compounds influence protein dynamics within different cell types. By inhibiting ATE1, scientists can dissect the precise role of arginylation in cellular regulation, protein maturation, and other intracellular processes critical for maintaining normal biological functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could downregulate ATE1 expression by preventing histone deacetylase from removing acetyl groups on histones, thereby tightening chromatin accessibility to the ATE1 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor may lead to the hypomethylation and subsequent transcriptional repression of the ATE1 gene, thereby reducing its expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By intercalating into DNA, Actinomycin D can inhibit RNA polymerase movement, leading to the blockage of the ATE1 mRNA synthesis, thus diminishing ATE1 protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin (Sirolimus) could downregulate ATE1 expression by specifically inhibiting mTORC1, a component of the mTOR pathway that is crucial for protein synthesis, including that of ATE1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may decrease ATE1 expression through retinoic acid receptor-mediated downregulation of gene expression, which includes genes involved in cell differentiation and growth. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
This estrogen could decrease ATE1 expression by binding to estrogen receptors, leading to altered transcriptional programs that may include the suppression of the ATE1 gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate may reduce ATE1 expression by causing hyperacetylation of histone proteins, leading to a closed chromatin state that is less permissive for the transcription of the ATE1 gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This chemical could inhibit ATE1 expression by blocking PI3K, leading to a decrease in AKT-mediated signaling and subsequent downregulation of several AKT-dependent transcription factors. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may decrease ATE1 expression by inhibiting NF-κB activation, which could lead to reduced transcription of NF-κB target genes, potentially including the gene coding for ATE1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could downregulate ATE1 expression by activating the SIRT1 deacetylase, leading to deacetylation of transcription factors and alteration of gene expression profiles. | ||||||