ATE1 Antibody (E-6): sc-271220

ATE1 Antibody (E-6) is a mouse monoclonal IgG1 light chain antibody that detects Arginyl-tRNA-protein transferase (ATE1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATE1 is a crucial enzyme in the posttranslational modification of proteins, specifically responsible for the arginylation of proteins that contain N-terminal aspartate, glutamate, and potentially cysteine residues. This modification is essential for targeting proteins for degradation via the ubiquitin-proteasome pathway, thereby regulating protein turnover and maintaining cellular homeostasis. ATE1 consists of 518 amino acids and exists in two distinct isoforms due to alternative splicing, which may have implications for functional diversity. ATE1 is predominantly localized in the cytoplasm and nucleus, where ATE1 plays a vital role in cellular processes, including stress responses and cell signaling. Anti-ATE1 antibody (E-6) is an invaluable tool for researchers studying protein degradation mechanisms and the broader implications of arginylation in various biological contexts.

The preferred ATE1 antibody is ATE1 Antibody (G-6): sc-398805.