Astrotactin Antibody (H-9): sc-514299
- Astrotactin Antibody (H-9) is a mouse monoclonal IgG1 κ Astrotactin antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 736-938 mapping within an internal region of Astrotactin of human origin
- Astrotactin Antibody (H-9) is recommended for detection of Astrotactin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Astrotactin Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Astrotactin Antibody (H-9) for WB applications. These reagents are now offered in bundles with Astrotactin Antibody (H-9) (see ordering information below).
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Astrotactin Antibody (H-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Astrotactin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Astrotactin antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Astrotactin plays a crucial role in neuronal migration within the central nervous system, a specialized form of cell motility essential for proper formation of the brain′s layered structure. Astrotactin is predominantly expressed on postmitotic neuronal precursors located in key brain regions such as the cerebellum, hippocampus, cerebrum, and olfactory bulb, where Astrotactin facilitates interactions between neurons and astrocytes, thereby influencing synaptic development and various neuronal functions. Structurally, Astrotactin contains three epidermal growth factor repeat domains and two fibronectin type III repeat domains, which are critical for interactions and functions. The human Astrotactin gene is located on chromosome 1q25 and exhibits significant homology to mouse counterpart, with mutations in this gene being associated with neuronal migration defects in both species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Astrotactin Antibody (H-9) References:
- Mice that lack astrotactin have slowed neuronal migration. | Adams, NC., et al. 2002. Development. 129: 965-72. PMID: 11861479
- Identification of two novel human genes, DIPLA1 and DIPAS, expressed in placenta tissue. | García, J. and Castrillo, JL. 2005. Gene. 344: 241-50. PMID: 15656990
- Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4. | Chen, YT., et al. 2005. Mol Cell Biol. 25: 2722-32. PMID: 15767677
- Cerebellar granule cells show age-dependent migratory differences in vitro. | Tárnok, K., et al. 2005. J Neurobiol. 65: 135-45. PMID: 16114030
- Antibodies that recognize astrotactin block granule neuron binding to astroglia. | Stitt, TN. and Hatten, ME. 1990. Neuron. 5: 639-49. PMID: 2223091
- Astrotactin: a novel neuronal cell surface antigen that mediates neuron-astroglial interactions in cerebellar microcultures. | Edmondson, JC., et al. 1988. J Cell Biol. 106: 505-17. PMID: 3276720
- CNS gene encoding astrotactin, which supports neuronal migration along glial fibers. | Zheng, C., et al. 1996. Science. 272: 417-9. PMID: 8602532
- Astrotactin provides a receptor system for CNS neuronal migration. | Fishell, G. and Hatten, ME. 1991. Development. 113: 755-65. PMID: 1821847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Astrotactin Antibody (H-9) | sc-514299 | 200 µg/ml | $316.00 | |||
Astrotactin Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-531085 | 200 µg Ab; 10 µg BP | $354.00 | |||
Astrotactin Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-524679 | 200 µg Ab, 40 µg BP | $354.00 | |||
Astrotactin Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-544389 | 200 µg Ab; 20 µg BP | $354.00 | |||
Astrotactin Antibody (H-9) AC | sc-514299 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Astrotactin Antibody (H-9) HRP | sc-514299 HRP | 200 µg/ml | $316.00 | |||
Astrotactin Antibody (H-9) FITC | sc-514299 FITC | 200 µg/ml | $330.00 | |||
Astrotactin Antibody (H-9) PE | sc-514299 PE | 200 µg/ml | $343.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 488 | sc-514299 AF488 | 200 µg/ml | $357.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 546 | sc-514299 AF546 | 200 µg/ml | $357.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 594 | sc-514299 AF594 | 200 µg/ml | $357.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 647 | sc-514299 AF647 | 200 µg/ml | $357.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 680 | sc-514299 AF680 | 200 µg/ml | $357.00 | |||
Astrotactin Antibody (H-9) Alexa Fluor® 790 | sc-514299 AF790 | 200 µg/ml | $357.00 |