Astrotactin Activators
Astrotactin activators are a diverse collection of chemical compounds that directly or indirectly enhance the functional activity of Astrotactin. These compounds act on a variety of targets, including receptors, enzymes, and second messengers, leading to enhanced Astrotactin activity. For instance, Retinoic Acid, a metabolite of vitamin A, enhances Astrotactin's function in neuronal migration by contributing to neuronal differentiation and neurite outgrowth. Compounds like N6-Cyclopentyladenosine (CPA), an adenosine receptor agonist, and Sphingosine-1-Phosphate (S1P), a bioactive lipid mediator, activate receptors that are crucial for cell migration and adhesion, thereby enhancing Astrotactin's function. Similarly, Forskolin and Rolipram, which increase the production of cAMP, and S-Nitroso-N-acetyl-DL-penicillamine (SNAP), a nitric oxide donorthat increases cGMP levels, influence second messenger systems to promote cellular processes like cell adhesion and migration. In turn, this enhances the activity of Astrotactin.
Other Astrotactin activators, such as Thrombin, Lysophosphatidic Acid (LPA), and Prostaglandin E2 (PGE2), act on different targets and pathways. For instance, Bradykinin stimulates the release of prostaglandins, Thrombin activates protease-activated receptors (PARs), and LPA and PGE2 activate their respective receptors. These processes all contribute to the modulation of intracellular signaling pathways involved in cell adhesion and migration, thereby enhancing Astrotactin's function. On the other hand, Spermine, a polyamine known to influence various intracellular signaling pathways, and Bisindolylmaleimide I (BIM), a potent and selective inhibitor of protein kinase C (PKC), can also enhance Astrotactin's activity by influencing the cellular processes in which it's involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that mediates the functions of vitamin A required for growth and development. Astrotactin is involved in neuronal migration during development, a process that can be enhanced by the presence of retinoic acid, which plays a role in neuronal differentiation and neurite outgrowth. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to increased production of cAMP. cAMP is a second messenger that can enhance various cellular processes, like cell adhesion and migration, where Astrotactin plays a significant role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid mediator that activates S1P receptors, crucial for cell migration and adhesion. The activation of these receptors can enhance Astrotactin's function in neuronal migration. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor, leading to increased cAMP levels. cAMP can enhance various cellular processes, including cell adhesion and migration, where Astrotactin plays a significant role. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is an enzyme that can activate protease-activated receptors (PARs). PARs can modulate a variety of intracellular signaling pathways involved in cell adhesion and migration, thereby enhancing Astrotactin's function. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
SNAP is a nitric oxide donor. Nitric oxide can activate guanylate cyclase, leading to increased cGMP levels. cGMP can modulate various cellular processes, including cell adhesion and migration, where Astrotactin plays a significant role. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA is a bioactive lipid that activates LPA receptors, which are involved in various cellular processes, including cell adhesion and migration. This can enhance Astrotactin's function in neuronal migration. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a bioactive lipid that activates PGE2 receptors. These receptors modulate various intracellular signaling pathways involved in cell adhesion and migration, thereby enhancing Astrotactin's function. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine involved in cell growth and function. It is known to influence various intracellular signaling pathways, including those involved in cell adhesion and migration, which can enhance the activity of Astrotactin. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM is a potent and selective inhibitor of protein kinase C (PKC). PKC is involved in a variety of intracellular signaling pathways that influence cell adhesion and migration. By inhibiting PKC, BIM can enhance the activity of Astrotactin. | ||||||