Arylsulfatase E Antibody (F-4): sc-393224

Arylsulfatase E Antibody (F-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Arylsulfatase E of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Arylsulfatase E antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Arylsulfatase E, also known as CDPX, CDPX1, or CDPXR, is a 589 amino acid protein located in the Golgi apparatus and is primarily expressed in the pancreas, liver, and kidney. Arylsulfatase E plays a crucial role in the hydrolysis of sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids, which is essential for hormone biosynthesis, modulation of cell signaling, and the degradation of macromolecules. Arylsulfatase E functions as part of the sulfatase family to maintain the correct composition of cartilage and bone matrix during development. Deficiencies in Arylsulfatase E can lead to chondrodysplasia punctata X-linked recessive type 1 (CDPX1), a condition characterized by abnormal bone mineralization and severe underdevelopment of nasal cartilage. Arylsulfatase E has no activity toward steroid sulfates, highlighting its specificity and importance in various biological processes.

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Arylsulfatase E Antibody (F-4) References:

1. Late diagnosis of maternal PKU in a family segregating an arylsulfatase [corrected] E mutation causing symmetrical chondrodysplasia punctata.  |  Dahl, HH., et al. 1999. Mol Genet Metab. 68: 503-6. PMID: 10607480
2. Brachytelephalangic dwarfism due to the loss of ARSE and SHOX genes resulting from an X;Y translocation.  |  Seidel, J., et al. 2001. Clin Genet. 59: 115-21. PMID: 11260213
3. X-linked recessive chondrodysplasia punctata: spectrum of arylsulfatase E gene mutations and expanded clinical variability.  |  Brunetti-Pierri, N., et al. 2003. Am J Med Genet A. 117A: 164-8. PMID: 12567415
4. Severe tracheobronchial stenosis in the X-linked recessive form of chondrodysplasia punctata.  |  Wolpoe, ME., et al. 2004. Arch Otolaryngol Head Neck Surg. 130: 1423-6. PMID: 15611404
5. Molecular cytogenetic analysis of a familial interstitial deletion Xp22.2-22.3 with a highly variable phenotype in female carriers.  |  Chocholska, S., et al. 2006. Am J Med Genet A. 140: 604-10. PMID: 16470742
6. Clinical and molecular analysis of arylsulfatase E in patients with brachytelephalangic chondrodysplasia punctata.  |  Nino, M., et al. 2008. Am J Med Genet A. 146A: 997-1008. PMID: 18348268
7. X-linked brachytelephalangic chondrodysplasia punctata: a simple trait that is not so simple.  |  Casarin, A., et al. 2009. Am J Med Genet A. 149A: 2464-8. PMID: 19839041
8. Potentiation of angiostatic steroids by a synthetic inhibitor of arylsulfatase.  |  Chen, NT., et al. 1988. Lab Invest. 59: 453-9. PMID: 2459497
9. The sulfatase gene family.  |  Parenti, G., et al. 1997. Curr Opin Genet Dev. 7: 386-91. PMID: 9229115

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Arylsulfatase E Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Arylsulfatase E Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Arylsulfatase E Antibody (F-4) Specifications

Alternate Product Name: Arylsulfatase E

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 513-534

Epitope Target: Arylsulfatase E

Epitope Species: human

Product Reactivity/Detection: Arylsulfatase E

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Arylsulfatase E Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin