ARL13B Antibody (D-10): sc-515832

ARL13B Antibody (D-10) is a mouse monoclonal IgG2a light chain antibody that detects ARL13B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARL13B, also known as ADP-ribosylation factor-like 13B or JBTS8, is a 428 amino acid protein that plays a crucial role in cilia formation, which is essential for various cellular processes, including signaling pathways and fluid movement. The proper functioning of cilia is vital for maintaining homeostasis in tissues and organs, and defects in ARL13B can lead to Joubert syndrome, a rare genetic disorder characterized by severe neurological impairments due to an underdeveloped cerebellum and brain stem. This highlights the importance of ARL13B not only in cellular structure but also in human health, making anti-ARL13B antibody (D-10) a valuable tool for researchers studying ciliary function and related disorders.

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ARL13B Antibody (D-10) References:

1. ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.  |  Humbert, MC., et al. 2012. Proc Natl Acad Sci U S A. 109: 19691-6. PMID: 23150559
2. Arl13b in primary cilia regulates the migration and placement of interneurons in the developing cerebral cortex.  |  Higginbotham, H., et al. 2012. Dev Cell. 23: 925-38. PMID: 23153492
3. Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.  |  Nozaki, S., et al. 2017. J Cell Sci. 130: 563-576. PMID: 27927754
4. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).  |  Ivanova, AA., et al. 2017. J Biol Chem. 292: 11091-11108. PMID: 28487361
5. A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.  |  Rafiullah, R., et al. 2017. Eur J Hum Genet. 25: 1324-1334. PMID: 29255182
6. Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation.  |  Bay, SN., et al. 2018. Proc Natl Acad Sci U S A. 115: 1570-1575. PMID: 29378965
7. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.  |  He, K., et al. 2018. Nat Commun. 9: 3310. PMID: 30120249
8. Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.  |  Thirugnanam, K., et al. 2022. Biochem Pharmacol. 202: 115143. PMID: 35700757
9. Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence.  |  Mahajan, D., et al. 2023. J Biol Chem. 299: 104604. PMID: 36907439
10. Induction of IMPDH-Based Cytoophidia by a Probable IMP-Dependent ARL13B-IMPDH Interaction.  |  Alijani, N. and Yazdanparast, R. 2024. Biochemistry (Mosc). 89: 2287-2291. PMID: 39865040

The preferred ARL13B antibody is ARL13B Antibody (C-5): sc-515784.