ARL13B Inhibitors

ARL13B, also known as ADP-ribosylation factor-like protein 13B, is a critical component of primary cilia, which are microtubule-based cellular protrusions found on the surface of most vertebrate cells. These cilia play essential roles in various cellular processes, including signal transduction, sensory perception, and cell motility. ARL13B, as a small GTPase belonging to the ADP-ribosylation factor family, is primarily localized to the ciliary membrane and is crucial for the proper structure and function of primary cilia. Its activity is tightly regulated, as any dysregulation can lead to ciliary defects associated with a range of developmental and genetic disorders, collectively known as ciliopathies.

ARL13B inhibitors refer to a class of chemical compounds designed to selectively modulate the activity of ARL13B. These inhibitors can either enhance or reduce the GTPase activity of ARL13B, influencing ciliary dynamics and associated cellular processes. By targeting ARL13B, researchers aim to unravel the intricate mechanisms governing ciliogenesis, ciliary signaling, and ciliary dysfunction-related diseases. These inhibitors serve as valuable tools for investigating the role of ARL13B in cellular functions and deciphering the underlying molecular pathways. They enable scientists to dissect the intricate ciliary signaling networks and unveil the complexities of ciliopathies at the molecular level. Moreover, the development of ARL13B inhibitors holds promise for advancing our understanding of ciliary-related biology and may eventually lead to innovative approaches for addressing ciliopathy-associated challenges in various fields.