ARFGAP2 Antibody (B-6): sc-398537
- ARFGAP2 Antibody (B-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 373-414 within an internal region of ARFGAP2 of human origin
- recommended for detection of ARFGAP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ARFGAP2 Antibody (B-6) for WB applications. These reagents are now offered in bundles with ARFGAP2 Antibody (B-6) (see ordering information below).
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ARFGAP2 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects ARFGAP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARFGAP2, also known as ZNF289, plays a crucial role as a GTPase-activating protein for the ADP-ribosylation factor (ARF) family, which is essential for regulating vesicle trafficking and signal transduction within eukaryotic cells. ARFGAP2 is primarily localized to the cytoplasmic side of the Golgi apparatus, where ARFGAP2 is involved in the assembly of coat proteins and the maintenance of organelle integrity. This localization enables ARFGAP2 to effectively coordinate interactions between ARF proteins and other cellular components, thereby influencing the dynamics of vesicle formation and transport. Additionally, ARFGAP2 contains one ARF-GAP domain and is associated with COP-I-coated vesicles, highlighting ARFGAP2′s importance in cellular processes that govern membrane trafficking and organelle function. Anti-ARFGAP2 antibody (B-6) serves as an invaluable tool for researchers studying the intricate mechanisms of cellular transport and signaling pathways.
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ARFGAP2 Antibody (B-6) References:
- Gamma-COP appendage domain - structure and function. | Watson, PJ., et al. 2004. Traffic. 5: 79-88. PMID: 14690497
- Two human ARFGAPs associated with COP-I-coated vesicles. | Frigerio, G., et al. 2007. Traffic. 8: 1644-55. PMID: 17760859
- Three homologous ArfGAPs participate in coat protein I-mediated transport. | Saitoh, A., et al. 2009. J Biol Chem. 284: 13948-13957. PMID: 19299515
- The GAP domain and the SNARE, coatomer and cargo interaction region of the ArfGAP2/3 Glo3 are sufficient for Glo3 function. | Schindler, C., et al. 2009. Traffic. 10: 1362-75. PMID: 19602196
- Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. | Bauer, MC., et al. 2011. Mol Biosyst. 7: 2196-204. PMID: 21528130
- Protein networks involved in vesicle fusion, transport, and storage revealed by array-based proteomics. | Bauer, M., et al. 2011. Methods Mol Biol. 781: 47-58. PMID: 21877276
- ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. | Shiba, Y., et al. 2013. Curr Biol. 23: 1945-51. PMID: 24076238
- Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling. | Lo, IC., et al. 2015. Dev Cell. 33: 189-203. PMID: 25865347
- The Arf-GDP-regulated recruitment of GBF1 to Golgi membranes requires domains HDS1 and HDS2 and a Golgi-localized protein receptor. | Quilty, D., et al. 2018. J Cell Sci. 132: PMID: 29507113
- ArfGAP3 regulates vesicle transport and glucose uptake in myoblasts. | Li, S., et al. 2023. Cell Signal. 103: 110551. PMID: 36476390
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARFGAP2 Antibody (B-6) | sc-398537 | 200 µg/ml | $322.00 | |||
ARFGAP2 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-538466 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARFGAP2 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-536088 | 200 µg Ab; 40 µg BP | $361.00 | |||
ARFGAP2 Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-545715 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARFGAP2 (B-6) Neutralizing Peptide | sc-398537 P | 100 µg/0.5 ml | $69.00 |