Aquaporin 9/AQP9 Antibody (G-3): sc-74409

AQP9 Antibody (G-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects AQP9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-AQP9 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP9, consisting of 295 amino acids, plays a crucial role in facilitating the transport of water and a range of noncharged solutes across cell membranes, which is vital for maintaining osmotic balance and cellular homeostasis. As a member of the aquaporin family, AQP9 is particularly important in tissues where rapid water movement is necessary, such as in the kidneys and brain. AQP9 is also known to be permeable to urea and glycerol, distinguishing AQP9 from other aquaporins that primarily transport water. Expression of AQP9 in various tissues underscores its significance in physiological processes, including renal water absorption and regulation of fluid balance in the body. Using AQP9 (G-3) antibody in research can provide valuable insights into the functional dynamics of aquaporins and their impact on cellular and systemic water transport mechanisms.

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Aquaporin 9/AQP9 Antibody (G-3) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer.  |  Huang, D., et al. 2017. Cell Death Dis. 8: e2894. PMID: 28640255
3. Role of AQP9 in transport of monomethyselenic acid and selenite.  |  Geng, X., et al. 2017. Biometals. 30: 747-755. PMID: 28798983
4. AQP9 promotes astrocytoma cell invasion and motility via the AKT pathway.  |  Lv, Y., et al. 2018. Oncol Lett. 16: 6059-6064. PMID: 30344749
5. Low expression of AQP9 and its value in hepatocellular carcinoma.  |  Gao, C., et al. 2021. Transl Cancer Res. 10: 1826-1841. PMID: 35116505
6. AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression.  |  Shi, Y., et al. 2022. Biochem Biophys Rep. 31: 101317. PMID: 35967760
7. miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9.  |  Shan, E., et al. 2023. Funct Integr Genomics. 23: 77. PMID: 36879069
8. Integrated multiomics analysis reveals changes in liver physiological function in Aqp9 gene knockout mice.  |  Cheng, Q., et al. 2023. Int J Biol Macromol. 245: 125459. PMID: 37353119
9. Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway.  |  Yu, M., et al. 2024. Pharmacol Res. 203: 107172. PMID: 38583685
10. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13.  |  Ma, T., et al. 1996. Genomics. 35: 543-50. PMID: 8812490
11. Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.  |  Ishibashi, K., et al. 1998. Biochem Biophys Res Commun. 244: 268-74. PMID: 9514918
12. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 9/AQP9 Antibody (G-3) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 9/AQP9 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 9/AQP9 Antibody (G-3) Specifications

Alternate Product Name: aquaporin 9

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 179-218

Epitope Target: AQP9

Epitope Species: human

Product Reactivity/Detection: AQP9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 9/AQP9 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin