AQP9 Inhibitors
AQP9 inhibitors belong to a specific category of chemical compounds designed to target Aquaporin-9 (AQP9), a membrane protein involved in the transport of water and certain solutes across biological membranes. Aquaporins are a family of transmembrane proteins that play a crucial role in regulating water homeostasis and the movement of various molecules across cell membranes. AQP9, in particular, is expressed in various tissues, including the liver, adipose tissue, and immune cells, where it facilitates the transport of water, glycerol, and other solutes. Inhibitors of AQP9 are designed to modulate the activity of this protein, which can have implications in various physiological processes.
Chemically, AQP9 inhibitors are compounds that are specifically designed to bind to the AQP9 protein and block its function. These inhibitors can vary in structure and mechanism of action, but their common goal is to reduce the permeability of AQP9 for water and solutes. By inhibiting AQP9, these compounds may affect processes such as glycerol transport in adipose tissue or water transport in liver cells, influencing metabolic and osmotic regulation. Understanding the structure-activity relationships of AQP9 inhibitors is essential for designing more potent and selective compounds, which can be valuable tools for studying the physiological roles of AQP9 and may have implications in various research fields.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin can potentially alter the expression of various proteins, including AQP9, through its interaction with cellular DNA and the subsequent activation of different signaling pathways. It is known to induce cellular stress, which might downregulate AQP9 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As a pyrimidine analog, Fluorouracil interferes with DNA synthesis and function, potentially affecting the transcription of genes including AQP9. Its action might result in altered expression of several proteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, known to modulate the expression of various genes. It might influence AQP9 expression through its interaction with signaling pathways and transcription factors. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
L-Sulforaphane has been shown to modulate gene expression. Its potential to inhibit AQP9 expression might be linked to its ability to interact with transcription factors and signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Derived from turmeric, curcumin has demonstrated potential in modulating gene expression. Its effect on AQP9 expression might be related to its ability to interact with transcription factors and signaling molecules. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, a catechin found in green tea, has been shown to influence gene expression. It might modulate AQP9 expression through its interaction with cellular signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone found in soybeans, genistein has potential to modulate gene expression. It might affect AQP9 expression through its estrogenic activity and interaction with signaling pathways. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic(III) oxide has the potential to modulate gene expression. Its effect on AQP9 expression might be associated with its ability to induce oxidative stress and interact with cellular signaling pathways. | ||||||