Aquaporin 4/AQP4 Antibody (F-7): sc-390636

AQP4 Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects Aquaporin 4 (AQP4) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AQP4 plays a crucial role in maintaining water homeostasis in various tissues, particularly in the brain and skeletal muscle, where AQP4 is predominantly localized to the sarcolemma of fast-twitch muscle fibers. This localization allows for efficient water transport across the cell membrane, which is essential for muscle contraction and overall muscle function. AQP4′s ability to facilitate rapid water movement is particularly important in osmotic regulation and cellular hydration, impacting processes such as muscle performance and recovery. AQP4 is also involved in the regulation of cerebrospinal fluid dynamics, highlighting AQP4′s significance in both muscular and neurological health. With broad species reactivity and versatility in various applications, anti-AQP4 antibody (F-7) serves as an invaluable tool for researchers studying the physiological and pathological roles of this important water channel protein.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Aquaporin 4/AQP4 Antibody (F-7) References:

1. AQP4 transfected into mouse cholangiocytes promotes water transport in biliary epithelia.  |  Splinter, PL., et al. 2004. Hepatology. 39: 109-16. PMID: 14752829
2. AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells.  |  Kong, H., et al. 2008. J Cell Sci. 121: 4029-36. PMID: 19033383
3. AQP4 knockout aggravates ischemia/reperfusion injury in mice.  |  Zeng, XN., et al. 2012. CNS Neurosci Ther. 18: 388-94. PMID: 22533723
4. Can anti-AQP4 antibody damage the blood-brain barrier?  |  Akaza, M., et al. 2014. Eur Neurol. 72: 273-7. PMID: 25323016
5. AQP4‑knockout alleviates the lipopolysaccharide‑induced inflammatory response in astrocytes via SPHK1/MAPK/AKT signaling.  |  Dai, W., et al. 2018. Int J Mol Med. 42: 1716-1722. PMID: 29956748
6. Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.  |  Chen, X., et al. 2021. Acta Neurol Belg. 121: 1649-1659. PMID: 32737792
7. AQP4-siRNA alleviates traumatic brain edema by altering post-traumatic AQP4 polarity reversal in TBI rats.  |  Lu, H., et al. 2020. J Clin Neurosci. 81: 113-119. PMID: 33222898
8. Regulation of aquaporin-4 expression in the central nervous system investigated using M23-AQP4 null mouse.  |  Pisani, F., et al. 2021. Glia. 69: 2235-2251. PMID: 34038017
9. Autophagy promotes membrane trafficking of NR2B to alleviate depression by inhibiting AQP4 expression in mice.  |  Liu, X., et al. 2022. Exp Cell Res. 419: 113298. PMID: 35961389
10. Neuroprotective Role of AQP4 Knockdown in Astrocytes After Oxygen-Glucose Deprivation.  |  Xing, X. and Zhang, S. 2024. Brain Behav. 14: e70107. PMID: 39444081

The preferred Aquaporin 4/AQP4 antibody is Aquaporin 4/AQP4 Antibody (4/18): sc-32739.