Aquaporin 1/AQP1 Antibody (B-11): sc-25287

AQP1 Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects AQP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-AQP1 antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP1, also known as aquaporin 1, is an integral membrane protein that facilitates water transport across cell membranes, essential for maintaining osmotic balance and proper cellular function. AQP1 expression is highest in erythrocytes and renal tubule cells, contributing to renal water absorption and fluid homeostasis regulation. AQP1 presence in these locations highlights a crucial role in physiological processes like urine concentration and blood volume maintenance. As part of a larger aquaporin family, AQP1 works alongside various isoforms that transport other small solutes, demonstrating diverse roles in cellular hydration and nutrient transport. AQP1 (B-11) monoclonal antibody serves as an essential tool for researchers studying water transport mechanisms and related physiological processes in various biological contexts.

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Aquaporin 1/AQP1 Antibody (B-11) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.  |  Preston, GM. and Agre, P. 1991. Proc Natl Acad Sci U S A. 88: 11110-4. PMID: 1722319
3. AQP1 expression analysis in human diseases: implications for proteomic characterization.  |  Magni, F., et al. 2008. Expert Rev Proteomics. 5: 29-43. PMID: 18282122
4. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.  |  Denker, BM., et al. 1988. J Biol Chem. 263: 15634-42. PMID: 3049610
5. Physiological and pathological impact of AQP1 knockout in mice.  |  Hua, Y., et al. 2019. Biosci Rep. 39: PMID: 31023968
6. AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.  |  Chen, M., et al. 2020. Cell Death Dis. 11: 193. PMID: 32188840
7. Structure and chromosomal localization of a human water channel (AQP3) gene.  |  Ishibashi, K., et al. 1995. Genomics. 27: 352-4. PMID: 7558005
8. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.  |  Yang, B., et al. 1995. J Biol Chem. 270: 22907-13. PMID: 7559426
9. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.  |  Deen, PM., et al. 1994. Science. 264: 92-5. PMID: 8140421
10. The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization.  |  Moon, C., et al. 1993. J Biol Chem. 268: 15772-8. PMID: 8340403
11. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.  |  Lee, MD., et al. 1996. J Biol Chem. 271: 8599-604. PMID: 8621489
12. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 1/AQP1 Antibody (B-11) has 125 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 1/AQP1 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 1/AQP1 Antibody (B-11) Specifications

Alternate Product Name: aquaporin 1

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 215-269

Epitope Target: AQP1

Epitope Species: human

Product Reactivity/Detection: AQP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 125 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 1/AQP1 Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin