AQP1 Inhibitors
AQP1 inhibitors belong to a class of chemical compounds designed to modulate the function of Aquaporin-1 (AQP1), a water channel protein that facilitates the movement of water molecules across cell membranes. AQP1 is particularly abundant in various tissues and cells, including kidney tubules, red blood cells, and endothelial cells, where it plays a crucial role in maintaining water homeostasis by enabling the rapid and selective transport of water across cell membranes. These channels not only facilitate the movement of water but also allow the passage of small solutes like glycerol and other uncharged molecules.
Inhibitors targeting AQP1 aim to interfere with its function in facilitating water transport across cell membranes by binding to specific regions of the AQP1 protein or altering its structural conformation. By inhibiting AQP1, these compounds disrupt the normal passage of water molecules through the channels, impacting cellular hydration, fluid balance, and osmotic regulation in tissues expressing AQP1.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
A flavonoid that inhibits AQP1 channel activity, potentially leading to decreased expression as a feedback mechanism. | ||||||
Tetraethylammonium chloride | 56-34-8 | sc-202834 | 25 g | $45.00 | 2 | |
Known to affect ion channels; may reduce AQP1 expression by altering ionic balance and cell signaling. | ||||||
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $81.00 $177.00 $434.00 $541.00 $883.00 $1479.00 $2244.00 | 1 | |
A diuretic that can decrease AQP1 expression in renal cells as part of its action to reduce fluid retention. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Loop diuretic; may influence AQP1 expression by affecting fluid balance and renal function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Another diuretic that can modulate AQP1 expression, especially in renal tissues, as part of its diuretic effect. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Can induce cellular stress, potentially leading to the downregulation of AQP1 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid that can modulate AQP1 expression as part of its broad anti-inflammatory and immunosuppressive effects. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Nonsteroidal anti-inflammatory drug; can affect AQP1 expression in response to altered inflammation pathways. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
May decrease AQP1 expression by influencing cellular signaling pathways and diuresis. | ||||||
D(−)Mannitol | 69-65-8 | sc-203020A sc-203020 | 50 g 100 g | $10.00 $19.00 | 2 | |
An osmotic diuretic; can influence AQP1 expression as part of its osmoregulatory effects in the kidney. | ||||||