APC4 Antibody (G-1): sc-374173
- APC4 Antibody (G-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 509-806 mapping near the C-terminus of APC4 of human origin
- recommended for detection of APC4 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for APC4 Antibody (G-1) for WB applications. These reagents are now offered in bundles with APC4 Antibody (G-1) (see ordering information below).
APC4 Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects APC4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APC4, also known as ANAPC4, is a crucial 808 amino acid component of the anaphase-promoting complex (APC), which plays a vital role in regulating the cell cycle by promoting the separation of sister chromatids during mitosis. The APC functions by ubiquitinating mitotic cyclins and other regulatory proteins, marking them for degradation, which is essential for the orderly progression of cell division. APC4 activity is tightly regulated by various factors, including CDC20 and CDH1, which enhance cyclin-ubiquitination activity, while MAD2 serves as an inhibitor, forming a complex that prevents APC activation. Understanding the interactions and regulatory mechanisms involving APC4 is critical, as dysregulation of the APC can lead to improper cell division and has been implicated in various cancers. Anti-APC4 antibody (G-1) is an invaluable tool for researchers studying the dynamics of the cell cycle and the molecular underpinnings of tumorigenesis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APC4 Antibody (G-1) | sc-374173 | 200 µg/ml | $322.00 | |||
APC4 Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-537926 | 200 µg Ab; 10 µg BP | $361.00 | |||
APC4 Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-535404 | 200 µg Ab; 40 µg BP | $361.00 | |||
APC4 Antibody (G-1): m-IgG1 BP-HRP Bundle | sc-545450 | 200 µg Ab; 20 µg BP | $361.00 |