AP-2β Antibody (1G6/2): sc-53161

AP-2β Antibody (1G6/2) is a mouse monoclonal IgG2b antibody that detects AP-2β in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). AP-2β, a splice variant of the AP-2α transcription factor, plays a crucial role in regulating gene expression by binding to specific DNA sequences, thereby influencing various biological processes, including cell differentiation and proliferation. AP-2β (1G6/2) antibody has been shown to detect protein that inhibits AP-2α activity, which can lead to altered expression of genes involved in tumorigenesis. AP-2β forms part of the OB2-1 transcription factor complex, which upregulates the proto-oncogene c-ErbB-2, a gene overexpressed in 25-30% of breast cancers, highlighting AP-2β′s potential role in cancer progression. Deleterious mutations in AP-2β have been associated with various developmental disorders, underscoring AP-2β′s importance in both normal physiology and disease states. Through interactions with other transcription factors and gene expression modulation, AP-2β serves as a vital component in understanding molecular mechanisms underlying various biological functions and pathologies.

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AP-2β Antibody (1G6/2) References:

1. GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation.  |  Ding, X., et al. 2006. Nucleic Acids Res. 34: 2570-8. PMID: 16698963
2. The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons.  |  Schmidt, M., et al. 2011. Dev Biol. 355: 89-100. PMID: 21539825
3. Transcription factor AP-2β suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner β-catenin.  |  Wang, F., et al. 2017. Mol Carcinog. 56: 1909-1923. PMID: 28277615
4. AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.  |  Van Otterloo, E., et al. 2018. Development. 145: PMID: 29229773
5. Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function.  |  Hicks, EA., et al. 2018. Invest Ophthalmol Vis Sci. 59: 2229-2239. PMID: 29715367
6. AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal.  |  Akula, M., et al. 2020. Exp Eye Res. 195: 108042. PMID: 32353428
7. Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.  |  Nakai, A., et al. 2020. Genetics. 216: 753-764. PMID: 32878901
8. Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18.  |  Raap, M., et al. 2021. J Mol Histol. 52: 1257-1264. PMID: 34117603
9. Conditional Deletion of AP-2β in the Periocular Mesenchyme of Mice Alters Corneal Epithelial Cell Fate and Stratification.  |  Walker, H., et al. 2021. Int J Mol Sci. 22: PMID: 34445433
10. Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes.  |  Taiyab, A., et al. 2022. J Neurosci Res. 100: 638-652. PMID: 34822722

The preferred AP-2β antibody is AP-2β Antibody (C-6): sc-390119.