AP-2β Antibody (C-6): sc-390119
- AP-2β Antibody (C-6) is a mouse monoclonal IgG1 κ AP-2β antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 130-216 of AP-2β of human origin
- AP-2 beta Antibody (C-6) is recommended for detection of AP-2β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-AP-2 beta Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-390119 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for AP-2β Antibody (C-6) for WB applications. This reagent is now offered in a bundle with AP-2β Antibody (C-6) (see ordering information below).
AP-2β Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-2 beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP-2β (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AP-2 beta protein functions as a key member of the AP-2 transcription factor family, which includes AP-2α and AP-2γ, and binds to the DNA consensus sequence CCCCAGGC to initiate transcription of specific genes. AP-2β, a splice variant of AP-2α, regulates gene expression related to cell growth and differentiation, particularly in breast cancer, where AP-2β inhibits AP-2 activity and modulates the expression of proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancers. AP-2β′s interaction with other transcription factors, such as the OB2-1 complex, highlights AP-2β′s significance in cellular processes and potential as a therapeutic target. AP-2β′s role in normal cellular functions, oncogenesis, and developmental biology makes AP-2β an important target for research and clinical applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AP-2β Antibody (C-6) References:
- Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. | Satoda, M., et al. 2000. Nat Genet. 25: 42-6. PMID: 10802654
- Genes encoding for AP-2beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance. | Nilsson, KW., et al. 2007. Neurosci Lett. 411: 233-7. PMID: 17123722
- Transcription factor AP-2β suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner β-catenin. | Wang, F., et al. 2017. Mol Carcinog. 56: 1909-1923. PMID: 28277615
- Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. | Williams, T., et al. 1988. Genes Dev. 2: 1557-69. PMID: 3063603
- Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8/18. | Raap, M., et al. 2021. J Mol Histol. 52: 1257-1264. PMID: 34117603
- Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes. | Taiyab, A., et al. 2022. J Neurosci Res. 100: 638-652. PMID: 34822722
- Cloning and characterization of a second AP-2 transcription factor: AP-2 beta. | Moser, M., et al. 1995. Development. 121: 2779-88. PMID: 7555706
- An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. | Buettner, R., et al. 1993. Mol Cell Biol. 13: 4174-85. PMID: 8321221
- Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. | Williamson, JA., et al. 1996. Genomics. 35: 262-4. PMID: 8661133
- A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. | Bosher, JM., et al. 1996. Oncogene. 13: 1701-7. PMID: 8895516
- Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis. | Moser, M., et al. 1997. Dev Dyn. 208: 115-24. PMID: 8989526
- Identification of ERF-1 as a member of the AP2 transcription factor family. | McPherson, LA., et al. 1997. Proc Natl Acad Sci U S A. 94: 4342-7. PMID: 9113991
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AP-2β Antibody (C-6) | sc-390119 | 200 µg/ml | $322.00 | |||
AP-2β Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-526124 | 200 µg Ab; 10 µg BP | $361.00 | |||
AP-2β Antibody (C-6) X | sc-390119 X | 200 µg/0.1 ml | $322.00 | |||
AP-2β Antibody (C-6) AC | sc-390119 AC | 500 µg/ml, 25% agarose | $424.00 | |||
AP-2β Antibody (C-6) HRP | sc-390119 HRP | 200 µg/ml | $322.00 | |||
AP-2β Antibody (C-6) FITC | sc-390119 FITC | 200 µg/ml | $336.00 | |||
AP-2β Antibody (C-6) PE | sc-390119 PE | 200 µg/ml | $349.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 488 | sc-390119 AF488 | 200 µg/ml | $364.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 546 | sc-390119 AF546 | 200 µg/ml | $364.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 594 | sc-390119 AF594 | 200 µg/ml | $364.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 647 | sc-390119 AF647 | 200 µg/ml | $364.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 680 | sc-390119 AF680 | 200 µg/ml | $364.00 | |||
AP-2β Antibody (C-6) Alexa Fluor® 790 | sc-390119 AF790 | 200 µg/ml | $364.00 |