alpha/beta Synuclein Antibody (Syn 202): sc-32281

α/β-synuclein Antibody (Syn 202) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect both α-synuclein and β-synuclein proteins across human, mouse, and rat species. α/β-synuclein monoclonal antibody (Syn 202) targets an epitope on human recombinant α/β-synuclein, and is recommended for application in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry techniques. Synucleins, including α-synuclein (also known as NACP), β-synuclein (PNP 14), and γ-synuclein (persyn or BCSG1), are presynaptic proteins that play crucial roles in synaptic regulation and neuronal plasticity, primarily within the brain. α-Synuclein is notably a component of Alzheimer′s disease amyloid plaques and is localized to neuronal cell bodies and synapses, where post-translational modifications, such as phosphorylation and ubiquitination, are essential for function and implicated in the pathology of neurodegenerative diseases like Parkinson′s disease. These modifications influence protein aggregation and toxicity, making them critical targets for research and therapeutic strategies. β-Synuclein is involved in hematopoietic cell differentiation, while γ-synuclein is linked to axonal pathology in Parkinson′s disease, highlighting the diverse roles of synuclein family members in neuronal health and disease. α/β-synuclein (Syn 202) antibody is available in both unconjugated form and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing flexibility for different experimental requirements. By recognizing both native and modified forms of synucleins, α/β-synuclein (Syn 202) monoclonal antibody serves as a valuable tool for investigating the molecular mechanisms underlying synaptic function and neurodegenerative disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-alpha/beta Synuclein Antibody (Syn 202) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-alpha/beta Synuclein Antibody (Syn 202) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

alpha/beta Synuclein Antibody (Syn 202) Specifications

Alternate Product Name: alpha synuclein

Product Clone Name: Syn 202

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: α/β-synuclein

Epitope Species: human

Product Reactivity/Detection: α-synuclein and β-synuclein

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for alpha/beta Synuclein Antibody (Syn 202): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred alpha Synuclein antibody is alpha Synuclein Antibody (211): sc-12767.