alpha Synuclein Antibody (211): sc-12767
- alpha Synuclein Antibody (211) is a mouse monoclonal IgG1 κ alpha Synuclein antibody, cited in 222 publications, provided at 200 µg/ml
- raised against amino acid 121-125 of α-synuclein of human origin
- alpha Synuclein Antibody (211) is recommended for detection of α-synuclein of human origin by WB, IP, IF and IHC(P)
- Anti-alpha Synuclein Antibody (211) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for alpha Synuclein Antibody (211) for WB and IHC(P) applications. These reagents are now offered in bundles with alpha Synuclein Antibody (211) (see ordering information below).
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α-synuclein Antibody (211) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target the human α-synuclein protein, also known as SNCA, synuclein, or NACP. Anti-α-synuclein antibody (211) recognizes the epitope encompassing amino acids 121-125 of α-synuclein, facilitating detection through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) applications. α-synuclein is a pivotal protein primarily expressed in neuronal cell bodies and synapses, where α-synuclein plays a crucial role in synaptic regulation and neuronal plasticity, essential for maintaining proper brain function and facilitating communication between neurons. α-synuclein is deeply involved in synaptic vesicle trafficking and neurotransmitter release, processes vital for efficient neuronal signaling. α-synuclein is implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson′s disease and Alzheimer′s disease, where abnormal aggregation is a hallmark of disease progression. Additionally, α-synuclein expression is modulated during hematopoietic cell differentiation, indicating broader significance in cellular processes beyond the nervous system. α-synuclein monoclonal antibody (211) is available in both unconjugated form and various conjugated forms, such as horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing researchers with versatile options for different experimental needs. α-synuclein (211) antibody is an invaluable tool for scientists investigating the molecular mechanisms of synuclein-related disorders and exploring the physiological functions of α-synuclein in both the nervous system and hematopoietic cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
alpha Synuclein Antibody (211) References:
- The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. | Iwai, A., et al. 1995. Neuron. 14: 467-75. PMID: 7857654
- Identification of two distinct synucleins from human brain. | Jakes, R., et al. 1994. FEBS Lett. 345: 27-32. PMID: 8194594
- Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. | Uéda, K., et al. 1993. Proc Natl Acad Sci U S A. 90: 11282-6. PMID: 8248242
- Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. | Polymeropoulos, MH., et al. 1997. Science. 276: 2045-7. PMID: 9197268
- NACP, a synaptic protein involved in Alzheimer's disease, is differentially regulated during megakaryocyte differentiation. | Hashimoto, M., et al. 1997. Biochem Biophys Res Commun. 237: 611-6. PMID: 9299413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
alpha Synuclein Antibody (211) | sc-12767 | 200 µg/ml | $322.00 | |||
alpha Synuclein Antibody (211): m-IgG Fc BP-HRP Bundle | sc-528259 | 200 µg Ab; 10 µg BP | $361.00 | |||
alpha Synuclein Antibody (211): m-IgGκ BP-HRP Bundle | sc-520592 | 200 µg Ab, 40 µg BP | $361.00 | |||
alpha Synuclein Antibody (211) AC | sc-12767 AC | 500 µg/ml, 25% agarose | $424.00 | |||
alpha Synuclein Antibody (211) HRP | sc-12767 HRP | 200 µg/ml | $322.00 | |||
alpha Synuclein Antibody (211) FITC | sc-12767 FITC | 200 µg/ml | $336.00 | |||
alpha Synuclein Antibody (211) PE | sc-12767 PE | 200 µg/ml | $349.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 488 | sc-12767 AF488 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 546 | sc-12767 AF546 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 594 | sc-12767 AF594 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 647 | sc-12767 AF647 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 680 | sc-12767 AF680 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) Alexa Fluor® 790 | sc-12767 AF790 | 200 µg/ml | $364.00 | |||
alpha Synuclein Antibody (211) B | sc-12767 B | 200 µg/ml | $326.00 |