Alpha 4 Antibody (C-5): sc-377414
- Alpha 4 Antibody (C-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 148-195 mapping within an internal region of Alpha 4 of human origin
- recommended for detection of Alpha 4 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Alpha 4 Antibody (C-5) for WB applications. This reagent is now offered in a bundle with Alpha 4 Antibody (C-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Alpha 4 Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects Alpha 4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Alpha 4 is a cytoplasmic protein that plays a crucial role in regulating signal transduction by associating with the surface IgM receptor, thereby influencing the catalytic activity of type 2A-related serine/threonine phosphatases, specifically protein phosphatase 2A (PP2A). This regulation helps maintain cellular homeostasis and signaling pathways essential for various cellular functions. Alpha 4 (C-5) antibody recognizes interactions with MID1, a protein linked to X-linked Opitz GBBB syndrome, where mutations can lead to developmental defects such as craniofacial, cardiac, and genital anomalies. The accumulation of PP2A catalytic subunit (PP2Ac) due to impaired E3 ubiquitin ligase activity of MID1 highlights Alpha 4′s importance in cellular regulation and disease pathology. Alpha 4 is predominantly expressed in heart, skeletal muscle, and pancreas tissues, and belongs to the IGBP1/TAP42 family, underscoring its significance in both normal physiology and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Alpha 4 Antibody (C-5) | sc-377414 | 200 µg/ml | $322.00 | |||
Alpha 4 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-552153 | 200 µg Ab; 40 µg BP | $361.00 |