ALK Antibody (F-12): sc-398791
- ALK Antibody (F-12) is a mouse monoclonal IgG2a κ ALK antibody, cited in 13 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 117-145 within an N-terminal extracellular domain of ALK of human origin
- ALK Antibody (F-12) is recommended for detection of ALK of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ALK Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ALK Antibody (F-12) for WB applications. These reagents are now offered in bundles with ALK Antibody (F-12) (see ordering information below).
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ALK Antibody (F-12) is a mouse monoclonal IgG2a kappa light chain antibody engineered to target the anaplastic lymphoma kinase (ALK) protein, also known as CD246 or ALK RTK. ALK is a receptor tyrosine kinase characterized by its distinct structure, which includes an N-terminal extracellular domain, a single transmembrane helix, and an intracellular kinase domain. This protein plays a crucial role in the development and function of the nervous system by regulating neuronal growth, differentiation, and survival. Additionally, ALK is implicated in various cancers, including anaplastic large cell lymphoma, non-small cell lung cancer, and neuroblastoma, where genetic alterations such as translocations lead to constitutive activation and drive oncogenic signaling pathways. ALK (F-12) monoclonal antibody specifically recognizes an epitope within amino acids 117-145 of the N-terminal extracellular domain of human ALK, ensuring high specificity and affinity for the target protein. Anti-ALK antibody (F-12) demonstrates robust reactivity with ALK from mouse, rat, and human origins across multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), making this tool indispensable for both basic and clinical research. By facilitating precise detection and analysis of ALK expression and activity, ALK (F-12) monoclonal antibody enables researchers to investigate ALK-related signaling mechanisms and develop targeted therapeutic strategies. Anti-ALK antibody (F-12) supports studies aimed at understanding ALK′s role in normal physiology and contribution to disease pathology, thereby advancing the development of effective diagnostic and treatment options.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ALK Antibody (F-12) References:
- Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain. | Haase, VH., et al. 1991. Oncogene. 6: 2319-25. PMID: 1662793
- Characterization of ROS1 cDNA from a human glioblastoma cell line. | Birchmeier, C., et al. 1990. Proc Natl Acad Sci U S A. 87: 4799-803. PMID: 2352949
- Cloning of mouse c-ros renal cDNA, its role in development and relationship to extracellular matrix glycoproteins. | Kanwar, YS., et al. 1995. Kidney Int. 48: 1646-59. PMID: 8544427
- The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. | Sonnenberg-Riethmacher, E., et al. 1996. Genes Dev. 10: 1184-93. PMID: 8675006
- Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. | Ueno, H., et al. 1996. J Biol Chem. 271: 27707-14. PMID: 8910363
- Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. | Iwahara, T., et al. 1997. Oncogene. 14: 439-49. PMID: 9053841
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALK Antibody (F-12) | sc-398791 | 200 µg/ml | $322.00 | |||
ALK Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-530930 | 200 µg Ab; 10 µg BP | $361.00 | |||
ALK Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-524488 | 200 µg Ab, 40 µg BP | $361.00 | |||
ALK Antibody (F-12): m-IgG2a BP-HRP Bundle | sc-547637 | 200 µg Ab; 10 µg BP | $361.00 | |||
ALK Antibody (F-12) AC | sc-398791 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ALK Antibody (F-12) HRP | sc-398791 HRP | 200 µg/ml | $322.00 | |||
ALK Antibody (F-12) FITC | sc-398791 FITC | 200 µg/ml | $336.00 | |||
ALK Antibody (F-12) PE | sc-398791 PE | 200 µg/ml | $349.00 | |||
ALK Antibody (F-12) Alexa Fluor® 488 | sc-398791 AF488 | 200 µg/ml | $364.00 | |||
ALK Antibody (F-12) Alexa Fluor® 546 | sc-398791 AF546 | 200 µg/ml | $364.00 | |||
ALK Antibody (F-12) Alexa Fluor® 594 | sc-398791 AF594 | 200 µg/ml | $364.00 | |||
ALK Antibody (F-12) Alexa Fluor® 647 | sc-398791 AF647 | 200 µg/ml | $364.00 | |||
ALK Antibody (F-12) Alexa Fluor® 680 | sc-398791 AF680 | 200 µg/ml | $364.00 | |||
ALK Antibody (F-12) Alexa Fluor® 790 | sc-398791 AF790 | 200 µg/ml | $364.00 | |||
ALK (F-12) Neutralizing Peptide | sc-398791 P | 100 µg/0.5 ml | $69.00 |