Aldose Reductase Antibody (H-6): sc-166918
- Aldose Reductase Antibody (H-6) is a mouse monoclonal IgG2b κ Aldose Reductase antibody, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 118-137 within an internal region of Aldose Reductase of mouse origin
- Aldose Reductase Antibody (H-6) is recommended for detection of Aldose Reductase of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Aldose Reductase Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aldose Reductase Antibody (H-6) for WB applications. These reagents are now offered in bundles with Aldose Reductase Antibody (H-6) (see ordering information below).
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Aldose Reductase Antibody (H-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects Aldose Reductase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Aldose Reductase antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aldose Reductase, also known as ALR2, is a crucial enzyme in the monomeric NADPH-dependent aldoketoreductase family, primarily responsible for catalyzing the reduction of aldehydes to their corresponding alcohols. This enzymatic activity is particularly significant in diabetic complications, as Aldose Reductase converts glucose into sorbitol, a sugar alcohol that accumulates in cells during hyperglycemia. The accumulation of sorbitol leads to osmotic and oxidative stress, contributing to the pathogenesis of diabetic neuropathy, retinopathy, and cataracts. Understanding Aldose Reductase function is vital for developing therapeutic strategies aimed at mitigating these complications. Aldose Reductase shares structural similarities with human aldehyde reductase (ALR1), bovine prostaglandin F synthase, and rho-crystallin found in the European common frog, highlighting evolutionary conservation and functional importance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Aldose Reductase Antibody (H-6) References:
- The human aldose reductase gene maps to chromosome region 7q35. | Graham, A., et al. 1991. Hum Genet. 86: 509-14. PMID: 1901827
- Cloning and expression of human aldose reductase. | Nishimura, C., et al. 1990. J Biol Chem. 265: 9788-92. PMID: 2112546
- The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. | Bohren, KM., et al. 1989. J Biol Chem. 264: 9547-51. PMID: 2498333
- Cloning and sequence determination of human placental aldose reductase gene. | Chung, S. and LaMendola, J. 1989. J Biol Chem. 264: 14775-7. PMID: 2504709
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldose Reductase Antibody (H-6) | sc-166918 | 200 µg/ml | $316.00 | |||
Aldose Reductase Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529087 | 200 µg Ab; 10 µg BP | $354.00 | |||
Aldose Reductase Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-521799 | 200 µg Ab, 40 µg BP | $354.00 | |||
Aldose Reductase Antibody (H-6): m-IgG2b BP-HRP Bundle | sc-550079 | 200 µg Ab; 10 µg BP | $354.00 | |||
Aldose Reductase Antibody (H-6) AC | sc-166918 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Aldose Reductase Antibody (H-6) HRP | sc-166918 HRP | 200 µg/ml | $316.00 | |||
Aldose Reductase Antibody (H-6) FITC | sc-166918 FITC | 200 µg/ml | $330.00 | |||
Aldose Reductase Antibody (H-6) PE | sc-166918 PE | 200 µg/ml | $343.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 488 | sc-166918 AF488 | 200 µg/ml | $357.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 546 | sc-166918 AF546 | 200 µg/ml | $357.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 594 | sc-166918 AF594 | 200 µg/ml | $357.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 647 | sc-166918 AF647 | 200 µg/ml | $357.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 680 | sc-166918 AF680 | 200 µg/ml | $357.00 | |||
Aldose Reductase Antibody (H-6) Alexa Fluor® 790 | sc-166918 AF790 | 200 µg/ml | $357.00 | |||
Aldose Reductase (H-6) Neutralizing Peptide | sc-166918 P | 100 µg/0.5 ml | $68.00 |