Aldehyde dehydrogenase 1B1/ALDH1B1 Antibody (C-7): sc-374090

ALDH1B1 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects ALDH1B1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH1B1, also known as Aldehyde dehydrogenase family 1 member B1 or Aldehyde dehydrogenase X (mitochondrial), is a crucial 517 amino acid mitochondrial protein primarily expressed in the liver and testis, with lower expression levels in the brain. ALDH1B1 plays a significant role in the detoxification of ethanol by catalyzing the conversion of acetaldehyde into less toxic acetic acid, thereby protecting cells from the harmful effects of alcohol metabolism. ALDH1B1′s importance extends beyond detoxification; ALDH1B1 is also involved in the metabolism of various biogenic amines and neurotransmitters, which are essential for maintaining normal physiological functions. Variants in the ALDH1B1 gene have been linked to alcohol consumption patterns and cardiovascular disease risk, highlighting ALDH1B1′s relevance in both metabolic processes and disease susceptibility. Anti-ALDH1B1 antibody (C-7) is an invaluable tool for researchers studying ALDH1B1′s role in various biological contexts and implications in health and disease.

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Aldehyde dehydrogenase 1B1/ALDH1B1 Antibody (C-7) References:

1. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.  |  Chen, Y., et al. 2011. Biochem Biophys Res Commun. 405: 173-9. PMID: 21216231
2. Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling.  |  Jackson, BC., et al. 2015. Pharm Res. 32: 1648-62. PMID: 25413692
3. ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.  |  Singh, S., et al. 2015. PLoS One. 10: e0121648. PMID: 25950950
4. Upregulation of ALDH1B1 promotes tumor progression in osteosarcoma.  |  Wang, X., et al. 2018. Oncotarget. 9: 2502-2514. PMID: 29416787
5. Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.  |  Mameishvili, E., et al. 2019. Proc Natl Acad Sci U S A. 116: 20679-20688. PMID: 31548432
6. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1.  |  Feng, Z., et al. 2022. Nat Chem Biol. 18: 1065-1075. PMID: 35788181
7. Aldehyde Dehydrogenase 1B1 Is Implicated in DNA Damage Response in Human Colorectal Adenocarcinoma.  |  Tsochantaridis, I., et al. 2022. Cells. 11: PMID: 35805102
8. Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells.  |  Wang, Y., et al. 2023. Chem Biol Interact. 384: 110714. PMID: 37716420
9. Prognostic and immunological role of acetaldehyde dehydrogenase 1B1 in human tumors: A pan-cancer analysis.  |  Kuang, Y., et al. 2023. Int J Immunopathol Pharmacol. 37: 3946320231206966. PMID: 37847172
10. Exploring the Role and Pathophysiological Significance of Aldehyde Dehydrogenase 1B1 (ALDH1B1) in Human Lung Adenocarcinoma.  |  Tsochantaridis, I., et al. 2024. Int J Mol Sci. 25: PMID: 39408636

The preferred Aldehyde dehydrogenase 1B1/ALDH1B1 antibody is Aldehyde dehydrogenase 1B1/ALDH1B1 Antibody (G-2): sc-393583.