Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (C-5): sc-398693

ALDH16A1 Antibody (C-5) is a mouse monoclonal IgG2a antibody that detects ALDH16A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH16A1 is an 802 amino acid protein that belongs to the aldehyde dehydrogenase superfamily, which is crucial for the metabolism of aldehyde substrates by utilizing nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. ALDH16A1 plays a significant role in oxidoreductase activity and protein binding, and has been shown to interact with Maspardin, a protein associated with Mast syndrome, highlighting ALDH16A1′s importance in cellular processes and potential implications in disease. The gene encoding ALDH16A1 is located on human chromosome 19q13.33 and produces two alternatively spliced isoforms, consisting of seventeen exons. ALDH16A1 is conserved across several species, including chimpanzee, dog, cow, mouse, rat, and zebrafish, although certain critical residues, such as a cysteine active site and glutamate residues, are not conserved, which may affect functional properties. With versatile applications and significant biological relevance, anti-ALDH16A1 antibody (C-5) serves as an essential tool for researchers studying this protein′s role in various physiological and pathological contexts.

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Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (C-5) References:

1. Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1.  |  Hanna, MC. and Blackstone, C. 2009. Neurogenetics. 10: 217-28. PMID: 19184135
2. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.  |  Vasiliou, V., et al. 2013. Chem Biol Interact. 202: 22-31. PMID: 23348497
3. Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function.  |  Charkoftaki, G., et al. 2017. Chem Biol Interact. 276: 15-22. PMID: 28254523
4. Duplications at 19q13.33 in patients with neurodevelopmental disorders.  |  Pérez-Palma, E., et al. 2018. Neurol Genet. 4: e210. PMID: 29473046
5. Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer.  |  Liu, LK. and Tanner, JJ. 2019. J Mol Biol. 431: 524-541. PMID: 30529746
6. Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1.  |  Pantouris, G., et al. 2019. Chem Biol Interact. 304: 168-172. PMID: 30894314
7. Genetic polymorphisms at 19q13.33 are associated with [-2]proPSA (p2PSA) levels and provide additional predictive value to prostate health index for prostate cancer.  |  Huang, D., et al. 2021. Prostate. 81: 971-982. PMID: 34254325
8. The ALDH Family Contributes to Immunocyte Infiltration, Proliferation and Epithelial-Mesenchymal Transformation in Glioma.  |  Wang, Z., et al. 2021. Front Immunol. 12: 756606. PMID: 35116021
9. Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis.  |  Gong, W., et al. 2023. JAMA Psychiatry. 80: 360-370. PMID: 36753304
10. Duplication at 19q13.32q13.33 Segregating with Neuropsychiatric Phenotype in a Three-Generation Family: Towards the Definition of a Critical Region.  |  Guadagnolo, D., et al. 2023. Genes (Basel). 14: PMID: 38136979

The preferred Aldehyde dehydrogenase 16-A1/ALDH16A1 antibody is Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1): sc-398657.