Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1): sc-398657

ALDH16A1 Antibody (E-1) is a mouse monoclonal IgM antibody that detects ALDH16A1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ALDH16A1 antibody (E-1) is available as the non-conjugated form. ALDH16A1 consists of 802 amino acids and belongs to the aldehyde dehydrogenase superfamily, known for catalyzing the oxidation of aldehydes to corresponding carboxylic acids - a crucial step in metabolizing various endogenous and exogenous compounds. ALDH16A1 (E-1) antibody helps study this enzyme′s role in detoxifying harmful aldehydes and maintaining cellular homeostasis. ALDH16A1 interacts with Maspardin, a protein associated with Mast syndrome, suggesting potential involvement in metabolic disorders. The ALDH16A1 gene is located on human chromosome 19q13.33 and produces two alternatively spliced isoforms with seventeen exons. While ALDH16A1 is conserved across several species, including chimpanzee, dog, cow, mouse, rat, and zebrafish, certain critical residues, such as a cysteine active site and specific glutamate residues, are not conserved, suggesting evolutionary divergence in function or regulation.

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Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1) References:

1. Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family.  |  Vasiliou, V. and Nebert, DW. 2005. Hum Genomics. 2: 138-43. PMID: 16004729
2. Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.  |  Marchitti, SA., et al. 2008. Expert Opin Drug Metab Toxicol. 4: 697-720. PMID: 18611112
3. Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1.  |  Hanna, MC. and Blackstone, C. 2009. Neurogenetics. 10: 217-28. PMID: 19184135
4. Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature.  |  Black, WJ., et al. 2009. Pharmacogenet Genomics. 19: 893-902. PMID: 19823103
5. A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.  |  Parikh, H., et al. 2010. Hum Genet. 127: 91-9. PMID: 19823874
6. Molecular coevolution of kisspeptins and their receptors from fish to mammals.  |  Um, HN., et al. 2010. Ann N Y Acad Sci. 1200: 67-74. PMID: 20633134
7. Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.  |  Soderblom, C., et al. 2010. Neurogenetics. 11: 369-78. PMID: 20661613
8. Rundataxin, a novel protein with RUN and diacylglycerol binding domains, is mutant in a new recessive ataxia.  |  Assoum, M., et al. 2010. Brain. 133: 2439-47. PMID: 20826435
9. 19q13.33→qter trisomy in a girl with intellectual impairment and seizures.  |  Carvalheira, G., et al. 2014. Meta Gene. 2: 799-806. PMID: 25606462
10. Genetic polymorphisms at 19q13.33 are associated with [-2]proPSA (p2PSA) levels and provide additional predictive value to prostate health index for prostate cancer.  |  Huang, D., et al. 2021. Prostate. 81: 971-982. PMID: 34254325
11. Detailed stratified GWAS analysis for severe COVID-19 in four European populations.  |  Degenhardt, F., et al. 2022. Hum Mol Genet. 31: 3945-3966. PMID: 35848942
12. Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.  |  Ambalavanan, A., et al. 2024. Nat Commun. 15: 7735. PMID: 39232002

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1) Specifications

Alternate Product Name: ALDH16A1

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 53-81

Epitope Target: ALDH16A1

Epitope Species: human

Product Reactivity/Detection: ALDH16A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Aldehyde dehydrogenase 16-A1/ALDH16A1 Antibody (E-1): P: Blocking Peptide