AIP2 Antibody (G-9): sc-166240
- AIP2 Antibody (G-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of AIP2 of human origin
- recommended for detection of AIP2 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AIP2 Antibody (G-9) for WB applications. These reagents are now offered in bundles with AIP2 Antibody (G-9) (see ordering information below).
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AIP2 Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects AIP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIP2, a member of the atrophin interacting protein family, plays a crucial role in cellular signaling and protein interactions, particularly in ubiquitin-mediated protein degradation. AIP2 is primarily located in the cytoplasm and interacts with various substrates, including those involved in neuronal signaling pathways. Multiple WW domains in AIP2 facilitate binding to proline-rich motifs in target proteins, which is essential for regulating cellular processes such as transcription and apoptosis. AIP2′s ability to form complexes with other proteins, including those linked to neurodegenerative diseases, underscores AIP2′s importance in maintaining cellular homeostasis and highlights AIP2′s potential as a therapeutic target. Anti-AIP2 antibody (G-9) is an invaluable tool for researchers investigating AIP2′s intricate roles in human health and disease.
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AIP2 Antibody (G-9) References:
- WWP2 Is One Promising Novel Oncogene. | Zhang, R., et al. 2019. Pathol Oncol Res. 25: 443-446. PMID: 30415470
- Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. | Zhang, N., et al. 2020. Cell Death Differ. 27: 2605-2619. PMID: 32139900
- Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. | Mahlokozera, T., et al. 2021. Nat Commun. 12: 6321. PMID: 34732716
- Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis. | Yang, C., et al. 2022. Regen Med. 17: 375-388. PMID: 35545948
- The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis. | Chen, H., et al. 2022. Nat Commun. 13: 7375. PMID: 36450710
- lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. | Zhang, Z., et al. 2023. Proc Natl Acad Sci U S A. 120: e2206694120. PMID: 36795754
- Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. | You, S., et al. 2023. Cardiovasc Diabetol. 22: 107. PMID: 37149668
- BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination. | Zhang, N., et al. 2023. Cell Discov. 9: 46. PMID: 37156792
- E3 ubiquitin ligase WWP2 as a promising therapeutic target for diverse human diseases. | You, S., et al. 2024. Mol Aspects Med. 96: 101257. PMID: 38430667
- WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts. | Chen, H., et al. 2024. J Am Soc Nephrol. 35: 696-718. PMID: 38502123
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AIP2 Antibody (G-9) | sc-166240 | 200 µg/ml | $322.00 | |||
AIP2 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-537459 | 200 µg Ab; 10 µg BP | $361.00 | |||
AIP2 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-534733 | 200 µg Ab; 40 µg BP | $361.00 |