AIP2 Antibody (A-3): sc-398090

AIP2 Antibody (A-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects AIP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AIP2 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AIP2 plays a crucial role in cellular processes by interacting with atrophin-1, particularly in the context of polyglutamine diseases, which are linked to neurodegenerative disorders such as Huntington′s disease. AIP2 is characterized by four WW domains, which are essential for protein-protein interactions, allowing binding to other proteins involved in signaling pathways and cellular regulation. The presence of a HECT domain in AIP2 suggests involvement in ubiquitin ligase activity, which is vital for protein degradation and turnover, thereby maintaining cellular homeostasis. AIP2′s interaction with other atrophin interacting proteins, such as AIP1 and AIP3, further emphasizes importance in the modulation of cellular functions and potential implications in disease mechanisms.

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AIP2 Antibody (A-3) References:

1. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology.  |  Nakamura, Y., et al. 2008. J Musculoskelet Neuronal Interact. 8: 321-2. PMID: 19147957
2. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.  |  Jiang, H., et al. 2022. J Biol Chem. 298: 101854. PMID: 35331737
3. LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.  |  Wang, Y., et al. 2022. Proc Natl Acad Sci U S A. 119: e2205629119. PMID: 36037365
4. Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.  |  Zhu, J., et al. 2023. IUBMB Life. 75: 595-608. PMID: 36773333
5. The role of WWP1 and WWP2 in bone/cartilage development and diseases.  |  Wang, Y., et al. 2024. Mol Cell Biochem. 479: 2907-2919. PMID: 38252355
6. WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis.  |  You, R., et al. 2024. J Adv Res.. PMID: 38909885
7. WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65.  |  André, B. and Springael, JY. 1994. Biochem Biophys Res Commun. 205: 1201-5. PMID: 7802651
8. The rsp5-domain is shared by proteins of diverse functions.  |  Hofmann, K. and Bucher, P. 1995. FEBS Lett. 358: 153-7. PMID: 7828727
9. The WW domain: a signalling site in dystrophin?  |  Bork, P. and Sudol, M. 1994. Trends Biochem Sci. 19: 531-3. PMID: 7846762
10. Identification of novel human WW domain-containing proteins by cloning of ligand targets.  |  Pirozzi, G., et al. 1997. J Biol Chem. 272: 14611-6. PMID: 9169421
11. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.  |  Perry, WL., et al. 1998. Nat Genet. 18: 143-6. PMID: 9462742
12. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.  |  Wood, JD., et al. 1998. Mol Cell Neurosci. 11: 149-60. PMID: 9647693

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AIP2 Antibody (A-3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-AIP2 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AIP2 Antibody (A-3) Specifications

Alternate Product Name: AIP2

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 30-57

Epitope Target: AIP2

Epitope Species: human

Product Reactivity/Detection: AIP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for AIP2 Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin