ADK Antibody (H-6): sc-514587

ADK Antibody (H-6) is a mouse monoclonal IgG2b antibody that detects adenosine kinase (ADK) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADK plays a crucial role in cellular metabolism by catalyzing the transfer of the gamma-phosphate from ATP to adenosine, thereby regulating the levels of extracellular adenosine and intracellular adenine nucleotides. This regulation is particularly important as adenosine acts as a signaling molecule that influences various physiological processes, including cardiovascular function, neuronal activity, and immune responses. Elevated levels of adenosine are often observed in tissues undergoing injury or inflammation, where adenosine serves to modulate the inflammatory response and protect against excessive neuronal excitability, making ADK a key player in maintaining homeostasis. The human ADK gene, located on chromosome 10q11-q24, produces two isoforms of the enzyme, differing in their N-terminal sequences, yet both exhibit similar enzymatic activity and require magnesium ions for function. Notably, while ADK is fully active in dilute solutions, ADK can form aggregates at higher concentrations, leading to enzyme inactivation, which underscores the importance of maintaining optimal conditions for activity in experimental settings. Anti-ADK antibody (H-6) is an essential tool for researchers studying the intricate roles of adenosine in health and disease.

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ADK Antibody (H-6) References:

1. Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues.  |  Kim, J., et al. 2008. Bioorg Med Chem Lett. 18: 4661-5. PMID: 18644717
2. Identification of functional motions in the adenylate kinase (ADK) protein family by computational hybrid approaches.  |  Armenta-Medina, D., et al. 2011. Proteins. 79: 1662-71. PMID: 21365689
3. Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy.  |  de Groot, M., et al. 2012. Epilepsia. 53: 58-66. PMID: 22092111
4. Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility.  |  Kimura, H., et al. 2018. Int J Neuropsychopharmacol. 21: 405-409. PMID: 29126171
5. Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice.  |  Zhang, M., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 2780-2792. PMID: 30571174
6. Immunogenicity and protective response induced by recombinant Brucella abortus proteins Adk, SecB and combination of these two recombinant proteins against a virulent strain B. abortus 544 infection in BALB/c mice.  |  Huy, TXN., et al. 2020. Microb Pathog. 143: 104137. PMID: 32169487
7. Genome-Wide Identification and Expression Analysis of Tomato ADK Gene Family during Development and Stress.  |  Yang, L., et al. 2021. Int J Mol Sci. 22: PMID: 34299327
8. Novel homozygous ADK out-of-frame deletion causes adenosine kinase deficiency with rare phenotypes of sepsis, metabolites disruption and neutrophil dysfunction.  |  Fan, S., et al. 2024. Gene. 914: 148313. PMID: 38447681
9. Genome-Wide Identification and Expression Analysis of ADK Gene Family Members in Cotton under Abiotic Stress.  |  Huang, P., et al. 2024. Int J Mol Sci. 25: PMID: 39063069
10. Interaction of H-2 and non-H-2 genes in spontaneous resistance to adenocarcinoma ADK-1t in F1 mice.  |  Forni, G., et al. 1980. J Natl Cancer Inst. 65: 651-5. PMID: 6931938

The preferred ADK antibody is ADK Antibody (H-1): sc-514588.