ACTR-IC Antibody (D-11): sc-376905

ACTR-IC Antibody (D-11) is a mouse monoclonal IgG2b antibody that detects ACTR-IC (Activin receptor type 1C) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ACTR-IC is a type I serine/threonine kinase receptor that plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. ACTR-IC is primarily located on the cell surface, where ACTR-IC interacts with ligands such as Activin AB, Activin B, and Nodal, facilitating important signaling pathways. ACTR-IC presence in the digestive and central nervous systems underscores ACTR-IC significance in maintaining physiological functions in these regions. Notably, ACTR-IC can form a complex with Activin receptor type IIB (ACTR-IIB) in pancreatic cells, which is essential for the activation of downstream Smad2 and Smad3 signaling pathways. ACTR-IC ability to induce apoptosis and inhibit proliferation in certain cell lines highlights ACTR-IC potential as a therapeutic target in diseases characterized by dysregulated cell growth. ACTR-IC Antibody (D-11) is an invaluable tool for researchers investigating the roles of this receptor in various biological contexts.

The preferred ACTR-IC antibody is ACTR-IC Antibody (A-1): sc-374538.