ACTR-IC Antibody (A-1): sc-374538

ACTR-IC Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ACTR-IC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ACTR-IC antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACTR-IC protein, also known as Activin receptor type 1C or Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor that plays a crucial role in cellular signaling pathways. ACTR-IC features an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box, and a transmembrane domain, which allows localization to the cell surface and interaction with various ligands. ACTR-IC is involved in regulating key biological processes, including cell proliferation and apoptosis, by forming complexes with other receptors such as Activin receptor type IIB (ACTR-IIB) in pancreatic cells. ACTR-IC kinase domain activates Smad2 and Smad3 signaling pathways, which are essential for mediating effects of Activin AB, Activin B, and Nodal. Alternative splicing of ACTR-IC results in four distinct transcripts, with the first being the functional full-length receptor, while others either lack a complete receptor binding domain or are soluble proteins devoid of a transmembrane domain. Diverse expression of ACTR-IC throughout the digestive and central nervous systems underscores its significance in various physiological and pathological contexts, making ACTR-IC monoclonal antibody (A-1) an invaluable tool for researchers studying these critical signaling pathways.

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ACTR-IC Antibody (A-1) References:

1. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.  |  DaCosta Byfield, S., et al. 2004. Mol Pharmacol. 65: 744-52. PMID: 14978253
2. Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.  |  Kim, BC., et al. 2004. J Biol Chem. 279: 28458-65. PMID: 15107418
3. Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.  |  Munir, S., et al. 2004. J Biol Chem. 279: 31277-86. PMID: 15150278
4. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7.  |  Xu, G., et al. 2004. J Clin Endocrinol Metab. 89: 5523-34. PMID: 15531507
5. Cartilage-derived morphogenetic proteins induce osteogenic gene expression in the C2C12 mesenchymal cell line.  |  Yeh, LC., et al. 2005. J Cell Biochem. 95: 173-88. PMID: 15759275
6. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta.  |  Tojo, M., et al. 2005. Cancer Sci. 96: 791-800. PMID: 16271073
7. Activin receptor-like kinase 7 induces apoptosis of pancreatic beta cells and beta cell lines.  |  Zhang, N., et al. 2006. Diabetologia. 49: 506-18. PMID: 16440210
8. Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines.  |  Xu, G., et al. 2006. Mol Cancer Res. 4: 235-46. PMID: 16603637
9. A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.  |  Rydén, M., et al. 1996. J Biol Chem. 271: 30603-9. PMID: 8940033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACTR-IC Antibody (A-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ACTR-IC Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACTR-IC Antibody (A-1) Specifications

Alternate Product Name: ACTR-IC

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 139-175

Epitope Target: ACTR-IC

Epitope Species: human

Product Reactivity/Detection: ACTR-IC isoforms 1 and 4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ACTR-IC Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin