ACTH/CLIP Antibody (E-12): sc-365831
- ACTH/CLIP Antibody (E-12) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 158-183 within an internal region of POMC of mouse origin
- recommended for detection of POMC and the processed active peptides ACTH and CLIP of mouse, rat and human origin by WB, IP, IF and ELISA
- See ACTH/CLIP (F-3): sc-373878 for ACTH/CLIP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ACTH/CLIP Antibody (E-12) for WB applications. These reagents are now offered in bundles with ACTH/CLIP Antibody (E-12) (see ordering information below).
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ACTH/CLIP Antibody (E-12) is a mouse monoclonal IgG2a kappa light chain antibody that specifically binds to an epitope mapping between amino acids 158-183 within an internal region of Pro-opiomelanocortin (POMC), also known as corticotropin-lipotropin. POMC is a polypeptide hormone precursor synthesized in the anterior pituitary gland and processed in secretory granules within corticotroph cells. This subcellular localization is crucial for the proper post-translational processing of POMC into multiple active peptides, including Adrenocorticotropic Hormone (ACTH) and Corticotropin-like Intermediate Peptide (CLIP). ACTH, also known as corticotropin, is a 39 amino acid peptide that stimulates cortisol secretion from the adrenal cortex, playing a vital role in stress response and metabolism. CLIP is a 21 amino acid neuropeptide secreted by corticotrope cells of the adenohypophysis, involved in various neurological functions. Mutations in the POMC gene can lead to POMC deficiency, characterized by red hair, adrenal insufficiency, and susceptibility to obesity. Anti-POMC antibody (E-12) reacts with POMC and its processed peptides ACTH and CLIP from mouse, rat, and human origins, and is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTH/CLIP Antibody (E-12) | sc-365831 | 200 µg/ml | $322.00 | |||
ACTH/CLIP Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-537844 | 200 µg Ab; 10 µg BP | $361.00 | |||
ACTH/CLIP Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-535266 | 200 µg Ab; 40 µg BP | $361.00 | |||
ACTH/CLIP (E-12) Neutralizing Peptide | sc-365831 P | 100 µg/0.5 ml | $69.00 |