Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (A-2): sc-166567

AChRβ1 Antibody (A-2) is a mouse monoclonal IgG2b antibody that detects AChRβ1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AChRβ1, also known as CHRNB, CMS1D, CMS2A, SCCMS, or CHRNB1, is a crucial component of the nicotinic acetylcholine receptor, which plays a vital role in neuromuscular transmission. This 501 amino acid protein is located at the postsynaptic membrane of the neuromuscular junction, where AChRβ1 binds acetylcholine, facilitating the influx of ions that trigger muscle contraction. The proper functioning of AChRβ1 is essential for muscle activation and coordination, and any defects in the gene encoding AChRβ1 can lead to congenital myasthenic syndrome slow-channel type (SCCMS), a condition characterized by muscle weakness affecting various muscle groups, including those responsible for eye movement and facial expressions. The ability of AChRβ1 to undergo conformational changes in response to acetylcholine binding is critical for function, as these changes allow for rapid transmission of signals across the synapse, ensuring effective communication between nerves and muscles. Anti-AChRβ1 antibody (A-2) is an invaluable tool for researchers studying neuromuscular disorders and the underlying mechanisms of synaptic transmission.

The preferred Nicotinic Acetylcholine Receptor beta 1/CHRNB1 antibody is Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148): sc-65813.