acetylated alpha Tubulin Antibody (6-11B-1): sc-23950

Acetylated α Tubulin Antibody (6-11B-1) is a mouse monoclonal IgG2b kappa light chain antibody raised against the outer arms of Strongylocentrotus purpuratus (Sea Urchin) sperm axonemes, specifically recognizing the acetylated form of alpha tubulin in mammalian species, zebrafish, Drosophila, and Xenopus. Alpha tubulin, in conjunction with beta tubulin, forms heterodimers that polymerize to create microtubules, essential components of the cytoskeleton responsible for maintaining cell shape, enabling intracellular transport, and facilitating cell division. Acetylation of α tubulin at lysine 40 is a critical post-translational modification that enhances microtubule stability and affects interactions with motor proteins, thereby influencing processes like intracellular trafficking, ciliary and flagellar movement, and cell signaling pathways. Understanding the function and regulation of acetylated α tubulin is important for insights into neurodegenerative diseases, cancer, and developmental biology. Anti-acetylated α tubulin antibody (6-11B-1) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), providing a valuable tool for researchers investigating microtubule dynamics and cytoskeletal organization across a variety of biological systems.

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acetylated alpha Tubulin Antibody (6-11B-1) References:

1. Quantification of acetylated tubulin.  |  Chesta, ME., et al. 2013. Cytoskeleton (Hoboken). 70: 297-303. PMID: 23596183
2. Acetylated α-tubulin is reduced in individuals with poor sperm motility.  |  Bhagwat, S., et al. 2014. Fertil Steril. 101: 95-104.e3. PMID: 24268707
3. Tubulin acetylation: responsible enzymes, biological functions and human diseases.  |  Li, L. and Yang, XJ. 2015. Cell Mol Life Sci. 72: 4237-55. PMID: 26227334
4. Acetylated tubulin is essential for touch sensation in mice.  |  Morley, SJ., et al. 2016. Elife. 5: PMID: 27976998
5. Acetylated alpha-tubulin in microtubules during mouse fertilization and early development.  |  Schatten, G., et al. 1988. Dev Biol. 130: 74-86. PMID: 3053299
6. Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals.  |  Saunders, HAJ., et al. 2022. Curr Biol. 32: 614-630.e5. PMID: 35081332
7. Acetylated α-tubulin alleviates injury to the dendritic spines after ischemic stroke in mice.  |  Yang, C., et al. 2023. CNS Neurosci Ther. 29: 2327-2338. PMID: 36965035
8. Reduced acetylated α-tubulin in SPAST hereditary spastic paraplegia patient PBMCs.  |  Wali, G., et al. 2023. Front Neurosci. 17: 1073516. PMID: 37144097
9. Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization.  |  Monteiro, P., et al. 2023. EMBO J. 42: e112812. PMID: 37403793
10. Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization.  |  Calogero, AM., et al. 2023. Int J Mol Sci. 24: PMID: 37569662

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-acetylated alpha Tubulin Antibody (6-11B-1) has 349 citations in a variety of scientific publications.

Primary antibodies like Anti-acetylated alpha Tubulin Antibody (6-11B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

acetylated alpha Tubulin Antibody (6-11B-1) Specifications

Alternate Product Name: acetylated α Tubulin

Product Clone Name: 6-11B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 149-448

Epitope Target: α Tubulin

Epitope Species: S. purpuratus

Product Reactivity/Detection: acetylated α Tubulin

Species Reactivity/Detection: mammalian species, S. purpuratus, zebrafish, Drosophila, Xenopus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 349 citations in various scientific publications

Available Conjugates/Forms for acetylated alpha Tubulin Antibody (6-11B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred alpha Tubulin antibody is alpha Tubulin Antibody (TU-02): sc-8035.