α Tubulin Inhibitors
α Tubulin inhibitors belong to a specific class of chemical compounds that are known for their ability to interact with and modulate the activity of α tubulin, a key component of microtubules. Microtubules are essential cytoskeletal structures found in eukaryotic cells, playing crucial roles in various cellular processes such as cell division, intracellular transport, and maintenance of cell shape. α Tubulin, as part of the heterodimeric protein complex with β tubulin, forms the building blocks of microtubules. Inhibitors of α tubulin typically exert their effects by binding to the protein, disrupting microtubule polymerization, and interfering with their dynamic instability. This results in the disruption of normal cellular functions that rely on microtubule dynamics, ultimately affecting processes like mitosis and cellular motility.
The inhibition of α tubulin presents a unique approach to modulate cellular activities, and these compounds have been extensively studied for their applications in research, specifically in studying cell biology and understanding the mechanisms of cellular processes. As a result, α tubulin inhibitors have become valuable tools for researchers seeking to unravel the complexities of the cytoskeleton and its impact on cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel is one of the first and most well-known α-tubulin inhibitors. It stabilizes microtubules, preventing their disassembly during cell division and leading to cell cycle arrest and apoptosis. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $85.00 $325.00 $1072.00 | 16 | |
Docetaxel is another widely used microtubule-stabilizing agent that interferes with cell division, leading to cancer cell death. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine is an anti-mitotic agent that disrupts microtubule formation, causing cell cycle arrest in metaphase and eventually cell death. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine is a natural compound found in the autumn crocus plant. It binds to tubulin and inhibits microtubule assembly, leading to cell cycle arrest. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Combretastatin A-4 and its analogs are a group of tubulin-binding agents that disrupt microtubule dynamics, leading to cell cycle arrest and tumor regression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that depolymerizes microtubules, causing cell cycle arrest and apoptosis. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts α tubulin polymerization, affecting microtubule formation in fungi by binding to tubulin, impeding mitosis. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Estramustine is a combination of an estrogen derivative and a nitrogen mustard alkylating agent. The estrogen part binds to tubulin, interfering with microtubule function. | ||||||
ABT 751 | 141430-65-1 | sc-361097 sc-361097A | 10 mg 50 mg | $179.00 $825.00 | ||
ABT-751 is a small molecule inhibitor that interferes with microtubule dynamics, leading to cell cycle arrest and cell death. | ||||||