A1Up Antibody (H-2): sc-515250
- A1Up Antibody (H-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 100-116 near the N-terminus of A1Up of human origin
- recommended for detection of A1Up of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for A1Up Antibody (H-2) for WB applications. These reagents are now offered in bundles with A1Up Antibody (H-2) (see ordering information below).
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A1Up Antibody (H-2) is a mouse monoclonal IgG2b antibody that detects A1Up in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). A1Up, also known as Ataxin-1 ubiquitin-like-interacting protein or UBQLN4, is a 601 amino acid protein that plays a crucial role in cellular processes by localizing to both the cytoplasm and nucleus, where A1Up associates with the endoplasmic reticulum. This localization enables A1Up to bind to signal sequences on proteins destined for the endoplasmic reticulum, facilitating proper processing and trafficking. A1Up functions as a homodimer and links Ataxin-1 with ubiquitin/proteasome pathways, which may assist in forming multimeric protein complexes within the nucleus, a process vital for maintaining cellular homeostasis and regulating gene expression. A1Up contains one ubiquitin-like domain and one UBA domain, and undergoes phosphorylation in response to DNA damage, highlighting A1Up′s potential involvement in cellular stress responses. Anti-A1Up antibody (H-2) serves as an essential tool for researchers studying A1Up′s intricate roles in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A1Up Antibody (H-2) | sc-515250 | 200 µg/ml | $322.00 | |||
A1Up Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-538762 | 200 µg Ab; 10 µg BP | $361.00 | |||
A1Up Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-536431 | 200 µg Ab; 40 µg BP | $361.00 | |||
A1Up Antibody (H-2): m-IgG2b BP-HRP Bundle | sc-549980 | 200 µg Ab; 10 µg BP | $361.00 | |||
A1Up (H-2) Neutralizing Peptide | sc-515250 P | 100 µg/0.5 ml | $69.00 |