17β-HSD4 Antibody (B-5): sc-271825

17β-HSD4 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects 17β-HSD4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 17β-HSD4, also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme, or 17-β Estradiol dehydrogenase type IV, plays a crucial role in regulating steroid availability across various tissues by inactivating estradiol through oxidative activity. Beyond involvement in steroid metabolism, 17β-HSD4 is essential for peroxisomal fatty acid and cholesterol β-oxidation, highlighting importance in lipid metabolism and energy homeostasis. A multi-domain structure, comprising a dehydrogenase domain fused with a hydratase and a lipid transfer domain, is critical for multifunctional enzymatic activities. 17β-HSD4 is a target protein of chromeceptin and is vital for downstream activation of Stat6, a key player in immune response and inflammation. Deficiencies in 17β-HSD4 can lead to severe conditions such as Zellweger-like syndrome, characterized by significant neurological and developmental challenges, including neuronal migration defects and facial dysmorphisms, ultimately resulting in high infant mortality. anti-17β-HSD4 antibody (B-5) is an invaluable tool for researchers studying intricate roles in both steroid metabolism and cellular function.

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17β-HSD4 Antibody (B-5) References:

1. Differential expression of 17beta-hydroxysteroid dehydrogenases types 2 and 4 in human endometrial epithelial cell lines.  |  Husen, B., et al. 2000. J Mol Endocrinol. 24: 135-44. PMID: 10657005
2. Evolution of 17beta-HSD type 4, a multifunctional protein of beta-oxidation.  |  Breitling, R., et al. 2001. Mol Cell Endocrinol. 171: 205-10. PMID: 11165031
3. Expression of estrogen receptor alpha and 17beta-hydroxysteroid dehydrogenase 4 in the ciliary body.  |  Kobayashi, K., et al. 2004. Graefes Arch Clin Exp Ophthalmol. 242: 172-176. PMID: 14634829
4. Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells.  |  Nagayoshi, Y., et al. 2005. Mol Hum Reprod. 11: 615-21. PMID: 16219629
5. Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.  |  Marchais-Oberwinkler, S., et al. 2013. J Med Chem. 56: 167-81. PMID: 23145773
6. Effects of polar oil related hydrocarbons on steroidogenesis in vitro in H295R cells.  |  Knag, AC., et al. 2013. Chemosphere. 92: 106-15. PMID: 23561572
7. Exercise facilitates the action of dietary DHA on functional recovery after brain trauma.  |  Wu, A., et al. 2013. Neuroscience. 248: 655-63. PMID: 23811071
8. Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders.  |  Azuma, K. and Inoue, S. 2019. Int J Mol Sci. 20: PMID: 31212662
9. In vitro evaluation for estrogenic mechanisms of the disinfectant benzalkonium chloride as an emerging contaminant.  |  Wei, S., et al. 2023. Braz J Med Biol Res. 56: e12784. PMID: 37493774
10. 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase expression in epithelial cells from hyperplastic and malignant human prostate.  |  Délos, S., et al. 1998. Int J Cancer. 75: 840-6. PMID: 9506528

The preferred 17β-HSD4 antibody is 17β-HSD4 Antibody (A-6): sc-365167.