17β-HSD Antibody (F-9): sc-365888
- 17β-HSD Antibody (F-9) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 171-328 mapping at the C-terminus of 17β-HSD of human origin
- recommended for detection of 17β-HSD of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 17β-HSD Antibody (F-9). This work is in progress.
17β-HSD Antibody (F-9) is a mouse monoclonal IgG2a antibody that detects 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 17β-HSD plays a crucial role in sex steroid biosynthesis, catalyzing the conversion of estrone to estradiol and androstenedione to testosterone, which are vital for various physiological processes including reproductive function and menstrual cycle regulation. 17β-HSD operates as a homodimer and exhibits a preference for NADP(H) over NAD(H), highlighting unique biochemical properties essential for steroid metabolism. 17β-HSD is predominantly expressed in ovarian granulosa cells and breast tissue, with additional expression in testis, placenta, uterus, prostate, and adipose tissue, indicating widespread influence on reproductive health. The gene encoding human 17β-HSD is located on chromosome 17q12-q21, and amplification has been associated with poor outcomes in breast cancer patients, particularly those undergoing tamoxifen treatment. This underscores the potential of targeting 17β-HSD for therapeutic interventions in breast cancer, making anti-17β-HSD antibody (F-9) a valuable tool for researchers studying cancer biology and hormone regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17β-HSD Antibody (F-9) | sc-365888 | 200 µg/ml | $322.00 |